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Merck

X4879

Sigma-Aldrich

Xaliproden

≥97% (HPLC), solid

Synonym(e):

1,2,3,6-Tetrahydro-1-[2-(2-naphthalenyl)ethyl]-4-[3-(trifluoromethyl)phenyl]pyridine -hydrochlorid, SR-57746A

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5 MG
152,00 €
25 MG
480,00 €

152,00 €


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5 MG
152,00 €
25 MG
480,00 €

About This Item

Empirische Formel (Hill-System):
C24H22F3N · HCl
CAS-Nummer:
Molekulargewicht:
417.89
MDL-Nummer:
UNSPSC-Code:
12352200
PubChem Substanz-ID:
NACRES:
NA.77

152,00 €


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Assay

≥97% (HPLC)

Form

solid

Farbe

white to off-white

Löslichkeit

DMSO: ≥5 mg/mL

Ersteller

Sanofi Aventis

Lagertemp.

2-8°C

SMILES String

Cl.FC(F)(F)c1cccc(c1)C2=CCN(CCc3ccc4ccccc4c3)CC2

InChI

1S/C24H22F3N.ClH/c25-24(26,27)23-7-3-6-22(17-23)20-11-14-28(15-12-20)13-10-18-8-9-19-4-1-2-5-21(19)16-18;/h1-9,11,16-17H,10,12-15H2;1H

InChIKey

WVHBEIJGAINUBW-UHFFFAOYSA-N

Angaben zum Gen

human ... HTR1A(3350)

Biochem./physiol. Wirkung

5-HT1A serotonin receptor agonist; neuroprotectant

Leistungsmerkmale und Vorteile

This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Piktogramme

Exclamation mark

Signalwort

Warning

H-Sätze

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)


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Die Dokumentenbibliothek aufrufen

Sherry Wolf et al.
European journal of cancer (Oxford, England : 1990), 44(11), 1507-1515 (2008-06-24)
Chemotherapy-induced peripheral neuropathy (CIPN) is a major dose limiting side effect of many commonly used chemotherapeutic agents, including platinum drugs, taxanes, epothilones and vinca alkaloids, and also newer agents such as bortezomib and lenolidamide. Symptom control studies have been conducted
A Appert-Collin et al.
International journal of immunopathology and pharmacology, 18(1), 21-31 (2005-02-09)
Motoneurons require neurotrophic factors for their survival and their differentiation. Xaliproden (SR57746A) is a synthetic compound that exhibits in vivo and in vitro neurotrophic effects in several experimental studies. Here we demonstrate that neuroprotective effects of Xaliproden on motoneuron cultures
P Murali Doraiswamy et al.
Expert opinion on pharmacotherapy, 7(1), 1-10 (2005-12-24)
This review examines key pharmacological strategies that have been clinically studied for the primary or secondary prevention of Alzheimer's disease. Much information (neuropsychological, genetic and imaging) is already available to characterise an individual's risk for developing Alzheimer's disease. However, regulatory
J P Terranova et al.
Neuroscience letters, 213(2), 79-82 (1996-08-02)
Different putative toxic amyloid beta (A beta) peptides, beta (1-42), beta (1-40) and beta (25-35), were infused (0.75, 1.5 or 3 nmol) in the rat medial septum. Memory deficits were then investigated using the social recognition test. A significant amnesia
Highlights From: the 2006 American Society of Clinical Oncology Gastrointestinal Cancers Symposium San Francisco, CA, January 2006.
Tara Beers Gibson et al.
Clinical colorectal cancer, 5(6), 398-402 (2006-04-26)

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