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V4765

Sigma-Aldrich

Valnoctamide

≥98% (NMR)

Synonym(e):

2-ethyl-3-methyl-pentanamide, Axiquel, Nirvanil

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5 MG
70,80 €
25 MG
218,00 €

70,80 €

Versandbereit am07. April 2025Details

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5 MG
70,80 €
25 MG
218,00 €

About This Item

Empirische Formel (Hill-System):
C8H17NO
CAS-Nummer:
4171-13-5
Molekulargewicht:
143.23
MDL-Nummer:
MFCD00868184
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329829054
NACRES:
NA.77

70,80 €

Versandbereit am07. April 2025Details

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Assay

≥98% (NMR)

Form

powder

Lagerbedingungen

desiccated

Farbe

white to off-white

Löslichkeit

DMSO: 20 mg/mL, clear

Lagertemp.

room temp

SMILES String

CCC(C)C(CC)C(N)=O

InChI

1S/C8H17NO/c1-4-6(3)7(5-2)8(9)10/h6-7H,4-5H2,1-3H3,(H2,9,10)

InChIKey

QRCJOCOSPZMDJY-UHFFFAOYSA-N

Anwendung

Valnoctamide has been used:
  • as a mood stabilizer to study its anti-cytomegalovirus (anti-CMV) effects in newborn mice brain [1]
  • as a hypnotic sedative to study its cytotoxic effects on oligodendrocyte precursor cells (OPCs) and human oligodendroglioma cell line (HOG) [2]
  • as a mood stabilizer to study its effects on inhibition of human cytomegalovirus [3]

Biochem./physiol. Wirkung

Valnoctamide exhibits anti-cytomegalovirus (anti-CMV) properties.[1] It has therapeutic effects against status epilepticus (SE) and neuropathic pain. Valnoctamide also shows therapeutic effects against bipolar disorders.[4]
Valproic acid (VPA) and derivatives such as valpromide and valnoctamide are anti-convulsant, mood stabilizing drugs, believed to function as indirect GABA agonists by inhibiting the transamination of GABA.

Leistungsmerkmale und Vorteile

This compound is featured on the Glutamate/GABA Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H302

Gefahreneinstufungen

Acute Tox. 4 Oral

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000194662
116M4751V
016M4728V
080M4749

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Die Dokumentenbibliothek aufrufen

Mood stabilizers inhibit cytomegalovirus infection
Ornaghi S, et al.
Virology, 499(29), 121-135 (2016)
M Bialer
Journal of controlled release : official journal of the Controlled Release Society, 62(1-2), 187-192 (1999-10-16)
Valproic acid (VPA) is one of the major antiepileptic drugs. However, its anticonvulsant potency is less than the other three major antiepileptic drugs. Furthermore, VPA causes two rare but severe side effects: teratogenicity and hepatotoxicity. We utilized pharmacokinetic considerations in
Amidic derivatives of valproic acid as antiviral in HSV-1-infected oligodendrocytes.
Praena B, et al.
Antiviral Research, 54(29), 99-102 (2019)
S Blotnik et al.
Drug metabolism and disposition: the biological fate of chemicals, 24(5), 560-564 (1996-05-01)
Valpromide (VPD) and valnoctamide (VCD) are amide derivatives of valproic acid (VPA), one of the major antiepileptic drugs (AEDs). In rodent models, both VPD and VCD are more potent as anticonvulsants than VPA. However, in humans, VPD served as a
M Radatz et al.
Epilepsy research, 30(1), 41-48 (1998-04-29)
The teratogenic properties of valproic acid (VPA) and its analogues depend to a great extent on their chemical structure. We investigated the structure-teratogenicity relationships of VPA, its structural isomer, valnoctic acid (VCA), and their two amide analogues, valpromide (VPD) and
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Artikel

Glutamate/GABA Synthesis & Metabolism

Glutamine's role in neurotransmitter synthesis and transport highlights its importance in neuronal function and glutamate production.

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