U104

UK 14,304

• Synonym(e): 5-Bromo-N-(2-imidazolin-2-yl)-6-quinoxalinamine, 5-Bromo-N-(4,5-dihydro-1H-imidazol-2-yl)-6-quinoxalinamine, Brimonidine
• Empirische Formel (Hill-System): C₁₁H₁₀BrN₅
• CAS-Nummer: 59803-98-4
• Molekulargewicht: 292.13
• MDL-Nummer: MFCD00153878
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24277812
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Löslichkeit: 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: <0.8 mg/mL; DMSO: >6.5 mg/mL; ethanol: <8 mg/mL (warm); H₂O: insoluble
• SMILES String: Brc1c(NC2=NCCN2)ccc3nccnc13
• InChI: 1S/C11H10BrN5/c12-9-7(17-11-15-5-6-16-11)1-2-8-10(9)14-4-3-13-8/h1-4H,5-6H2,(H2,15,16,17)
• InChIKey: XYLJNLCSTIOKRM-UHFFFAOYSA-N
• Angaben zum Gen: human ... ADRA1A(148) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

Beschreibung

Anwendung

UK 14,304 has been used for the activation of extracellular signal-regulated kinase (ERK) in epicardial coronary artery culture

UK 14,304 has been used in myenteric neurons to study the inhibition of R-type calcium currents. UK 14,304 has also been used for immunofluorescence microscopy assays.

Biochem./physiol. Wirkung

UK 14,304 is an α2-adrenoceptor agonist. UK 14,304 inhibits hormone-sensitive lipase (HSL) activity and suppresses lipogenesis in adipose tissue.

Leistungsmerkmale und Vorteile

This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Angaben zur Herstellung

UK 14,304 is soluble in 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin (<0.8 mg/mL), DMSO (>6.5 mg/ml) and ethanol (<8 mg/mL). However, it is insoluble in water.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301
• P-Sätze: P264 - P270 - P301 + P310 - P405 - P501
• Gefahreneinstufungen: Acute Tox. 3 Oral
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable