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T7947

Sigma-Aldrich

(R)-Tomoxetin -hydrochlorid

solid

Synonym(e):

(R)-N-Methyl-γ-(2-methyl­phenoxy)-benzolpropanamin -hydrochlorid

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25 MG
548,00 €
100 MG
1.480,00 €

548,00 €

Versandbereit am09. April 2025Details

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25 MG
548,00 €
100 MG
1.480,00 €

About This Item

Empirische Formel (Hill-System):
C17H21NO · HCl
CAS-Nummer:
82248-59-7
Molekulargewicht:
291.82
MDL-Nummer:
MFCD06410992
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24278760
NACRES:
NA.77

548,00 €

Versandbereit am09. April 2025Details

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Form

solid

Ersteller

Eli Lilly

Lagertemp.

2-8°C

SMILES String

CNCC[C@@H](OC1=CC=CC=C1C)C2=CC=CC=C2.[H]Cl

InChI

1S/C17H21NO.ClH/c1-14-8-6-7-11-16(14)19-17(12-13-18-2)15-9-4-3-5-10-15;/h3-11,17-18H,12-13H2,1-2H3;1H/t17-;/m1./s1

InChIKey

LUCXVPAZUDVVBT-UNTBIKODSA-N

Angaben zum Gen

human ... SLC6A2(6530)

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Anwendung

(R)-Tomoxetine hydrochloride has been used as a noradrenaline reuptake inhibitor:
  • to study the role of L-threo-3,4-dihydroxyphenylserine (L-DOPS) in the pathogenesis of Alzheimer′s disease in mice[1]
  • to study its effects on set shifting in rats[2]
  • to study its effects on rat brain as a result of its long-term use[3]

Biochem./physiol. Wirkung

(R)-Tomoxetine hydrochloride is an efficient inhibitor of presynaptic norepinephrine transporters.[4] It also positively regulates the release of acetylcholine in the prefrontal cortex (PFC).[2] (R)-Tomoxetine hydrochloride binds to the serotonin (5-HT) transporter.[2] It is involved in blocking the cortical N-methyl-D-aspartate (NMDA) receptors.[2]. (R)-Tomoxetine hydrochloride exhibits therapeutic effects against attention-deficit/hyperactivity disorder (ADHD) and comorbid oppositional defiant disorder (ODD).[4]
Norepinephrine uptake blocker.

Leistungsmerkmale und Vorteile

This compound is featured on the Biogenic Amine Transporters page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Eli Lilly. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000272353
074M4729V
080M4736V
028K47025
028K47024

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Die Dokumentenbibliothek aufrufen

Chi-Yung Shang et al.
Journal of child and adolescent psychopharmacology, 22(5), 353-363 (2012-10-23)
Atomoxetine is efficacious in reducing symptoms of attention- deficit/hyperactivity disorder (ADHD), but its effect on visual memory and attention needs more investigation. This study aimed to assess the effect of atomoxetine on visual memory, attention, and school function in boys
Grazia Dell'Agnello et al.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 19(11), 822-834 (2009-09-01)
The primary aim of this study was to assess the efficacy of atomoxetine in improving ADHD and ODD symptoms in paediatric patients with ADHD and comorbid oppositional defiant disorder (ODD), non-responders to previous psychological intervention with parent support. This was
Romano Arcieri et al.
Journal of child and adolescent psychopharmacology, 22(6), 423-431 (2013-01-31)
The purpose of this study was to assess the cardiovascular effects of drugs used for attention-deficit/hyperactivity disorder (ADHD) in children and adolescents treated in community care centers in Italy. This study was an open, prospective, observational study of youth with
Christina A Wilson et al.
Pharmacology, biochemistry, and behavior, 104, 47-61 (2013-01-05)
Rats repeatedly exposed to variable prenatal stress (PNS) exhibit behavioral signs that are similar to those manifested in several neuropsychiatric disorders such as deficits in attention and inhibitory control, and impairments in memory-related task performance. The purpose of the study
Nora D Volkow et al.
The New England journal of medicine, 369(20), 1935-1944 (2013-11-15)
Short-term trials involving adults with ADHD have shown significant improvements in symptoms with stimulants and atomoxetine; however, data on long-term benefits and risks of these medications, particularly among older persons, have been insufficient.
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