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T7450

Sigma-Aldrich

T62

≥98% (HPLC), crystalline

Synonym(e):

2-Amino-3-(4-chlorobenzoyl)-5,6,7,8-tetrahydrobenzothiophene

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About This Item

Empirische Formel (Hill-System):
C15H14ClNOS
CAS-Nummer:
40312-34-3
Molekulargewicht:
291.80
MDL-Nummer:
MFCD02738687
UNSPSC-Code:
12352204
PubChem Substanz-ID:
24724635

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

crystalline

Farbe

orange

Löslichkeit

DMSO: ~20 mg/mL
H2O: insoluble

Lagertemp.

2-8°C

SMILES String

Nc1sc2CCCCc2c1C(=O)c3ccc(Cl)cc3

InChI

1S/C15H14ClNOS/c16-10-7-5-9(6-8-10)14(18)13-11-3-1-2-4-12(11)19-15(13)17/h5-8H,1-4,17H2

InChIKey

OTZVBZFYMFTYKH-UHFFFAOYSA-N

Angaben zum Gen

human ... ADORA1(134)

Biochem./physiol. Wirkung

Allosteric enhancer of A1 adenosine receptor.
Studies in carrageenin-inflamed rats have reported that T62 can reverse thermal hypersensitivity[1]. T62 has also been reported to reduce mechanical allodynia and induce drug tolerance over time in rat models of neuropathic pain[2].

Angaben zur Herstellung

T62 is soluble in DMSO at approximately 20 mg/ml and is insoluble in water.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
051M4770
124K4614

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Die Dokumentenbibliothek aufrufen

Xinhui Li et al.
The Journal of pharmacology and experimental therapeutics, 305(3), 950-955 (2003-02-28)
Activation of adenosine A1 receptors by endogenous adenosine or synthetic agonists produces antinociception in animal models of acute pain and also reduces hypersensitivity in models of inflammatory and nerve-injury pain. Allosteric adenosine modulators facilitate and potentiate the action of adenosine
Hideaki Obata et al.
Anesthesiology, 100(5), 1258-1262 (2004-04-29)
Intrathecal adenosine has antinociceptive effects under conditions of hypersensitivity. T62 (2-amino-3-(4-chlorobenzoyl)-5,6,7,8-tetrahydrobenzothiophen) is an allosteric adenosine receptor modulator that enhances adenosine binding to the A1 receptor. Intrathecal T62 reduces hypersensitivity to mechanical stimuli in a rat model of neuropathic pain by
Xinhui Li et al.
Anesthesiology, 100(4), 956-961 (2004-04-17)
The positive allosteric adenosine receptor modulator, T62 (2-amino-3-(4-chlorobenzoyl)-5,6,7,8-tetrahydrobenzothiophene), has been shown to reduce mechanical allodynia in a rat model of neuropathic pain. However, whether chronic oral T62 retains efficacy in this pain model has not been examined. Therefore, the authors
Willem Soudijn et al.
Drug discovery today, 9(17), 752-758 (2004-09-29)
Allosteric modulation of G protein-coupled receptors has recently been recognized as an alternative approach to gain selectivity in drug action. In this overview, allosteric modulators that enhance or diminish the effects of (endogenous) agonists or antagonists on a variety of
Sarah R Bilskey et al.
SLAS technology, 25(5), 494-504 (2020-03-01)
The quantitation of sugars, including glucose, the primary fermentable sugar; maltose (DP2); and maltotriose (DP3), is a standard procedure during the corn-to-ethanol fermentation process. The quantitation of glucose by the Megazyme Assay utilizing glucose oxidase and peroxidase enzymes (GOPOD) and

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