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T7329

Sigma-Aldrich

Taurolidin

>97% (NMR), powder

Synonym(e):

4,4′-Methylenebis(tetrahydro-1,2,4-sulfadiazine 1,1-dioxide), Taurolin, Tauroline

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5 MG
152,00 €
25 MG
608,00 €

152,00 €

Versandbereit am02. April 2025Details

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5 MG
152,00 €
25 MG
608,00 €

About This Item

Empirische Formel (Hill-System):
C7H16N4O4S2
CAS-Nummer:
19388-87-5
Molekulargewicht:
284.36
EG-Nummer:
243-016-5
MDL-Nummer:
MFCD00865076
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329826864
NACRES:
NA.77

152,00 €

Versandbereit am02. April 2025Details

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Assay

>97% (NMR)

Form

powder

Lagerbedingungen

protect from light

Farbe

white to off-white

Löslichkeit

DMSO: >20 mg/mL

Lagertemp.

room temp

SMILES String

O=S1(=O)CCN(CN1)CN2CCS(=O)(=O)NC2

InChI

1S/C7H16N4O4S2/c12-16(13)3-1-10(5-8-16)7-11-2-4-17(14,15)9-6-11/h8-9H,1-7H2

InChIKey

AJKIRUJIDFJUKJ-UHFFFAOYSA-N

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Biochem./physiol. Wirkung

Taurolidine is a broad spectrum antibiotic with antineoplastic activity, which induces apoptosis and decreases tumor cell proliferation. Taurolidine has been used with TNF-related-apoptosis-inducing ligand (TRAIL) to characterize synergistic responses in many apoptosis related signaling-proteins. Tauroline is also being used as a tool to study the various mechanisms of apoptosis and necrosis.
Taurolidine is a broad spectrum antibiotic with antineoplastic activity; induces apoptosis and decreases tumor cell proliferation.
Taurolidine is an antibacterial agent that can be used for the treatment of peritonis. It has also been used as an antiendoxic substance for systematic inflammatory response syndrome and as an anti-angiogenic agent for tumors[1]. Furthermore, studies have reported that taurolidine can be used for the prevention of multiple catheter-related bloodstream infections[2].

Angaben zur Herstellung

Taurolidine is soluble in DMSO at a concentration that is greater than 20 mg/ml.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
080M4744
049K47182
049K47181
049K4718

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Justyna Schubert et al.
Scientific reports, 10(1), 10341-10341 (2020-06-27)
For decades, intraperitoneal chemotherapy (IPC) was delivered into the abdominal cavity as a liquid solution. This preliminary study aims to evaluate foam as a potential new drug carrier for IPC delivery. Foam-based intraperitoneal chemotherapy (FBIC) was produced with taurolidine, hydrogen
Kevin Marley et al.
BMC veterinary research, 9, 15-15 (2013-01-22)
Osteosarcoma (OS) affects over 8000 dogs/year in the United States. The disease usually arises in the appendicular skeleton and metastasizes to the lung. Dogs with localized appendicular disease benefit from limb amputation and chemotherapy but most die within 6-12 months
Mette Møller Handrup et al.
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 120(10), 794-801 (2012-09-11)
Taurolidine has demonstrated inhibition of biofilm formation in vitro. The aim of this study was to compare the effect of catheter locking with taurolidine vs heparin in biofilm formation in central venous catheters. Forty-eight children with cancer were randomized to
ESPGHAN/ESPEN/ESPR/CSPEN guidelines on pediatric parenteral nutrition: Venous access.
S Kolaček et al.
Clinical nutrition (Edinburgh, Scotland), 37(6 Pt B), 2379-2391 (2018-07-30)
Christoph A Jacobi et al.
Anti-cancer drugs, 16(9), 917-921 (2005-09-16)
Taurolidine [bis(1,1-dioxoperhydro-1,2,4-thiadiazinyl-4)-methane (TRD)], a product derived from the aminosulfoacid taurin, was first described as an anti-bacterial substance. It was mainly used in the treatment of patients with peritonis as well as antiendoxic agent in patients with systematic inflammatory response syndrome.
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