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Dokumente

T7313

Sigma-Aldrich

1-[2-(Trifluoromethyl)phenyl]imidazole

Synonym(e):

TRIM

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About This Item

Empirische Formel (Hill-System):
C10H7F3N2
CAS-Nummer:
25371-96-4
Molekulargewicht:
212.17
MDL-Nummer:
MFCD00041206
UNSPSC-Code:
12352202
PubChem Substanz-ID:
24278754
NACRES:
NA.77

Biologische Quelle

synthetic (organic)

Qualitätsniveau

200

Assay

≥98% (GC)

Form

solid

Löslichkeit

DMSO: soluble 30 mg/mL

Lagertemp.

2-8°C

SMILES String

FC(F)(F)c1ccccc1-n2ccnc2

InChI

1S/C10H7F3N2/c11-10(12,13)8-3-1-2-4-9(8)15-6-5-14-7-15/h1-7H

InChIKey

WZBWBNCQUTXYEL-UHFFFAOYSA-N

Angaben zum Gen

human ... NOS1(4842) , NOS2(4843) , NOS2B(201288) , NOS2C(645740) , NOS3(4846)

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Biochem./physiol. Wirkung

Potent nitric oxide synthase inhibitor. Because of the putative involvement of nitric oxide in depression and stress syndromes, TRIM was studied for its antidepressant effects, and found to reduce manifestations of stress in an animal model as well as fluoxetine.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

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Amélie Wallenhammar et al.
PloS one, 12(7), e0181551-e0181551 (2017-07-29)
Tripartite motif-containing (TRIM) proteins are defined by the sequential arrangement of RING, B-box and coiled-coil domains (RBCC), where the B-box domain is a unique feature of the TRIM protein family. TRIM21 is an E3 ubiquitin-protein ligase implicated in innate immune
Yves Basset et al.
Ecology and evolution, 7(23), 9991-10004 (2017-12-15)
We have little knowledge of the response of invertebrate assemblages to climate change in tropical ecosystems, and few studies have compiled long-term data on invertebrates from tropical rainforests. We provide an updated list of the 72 species of Saturniidae moths
Juan Traba et al.
Scientific reports, 9(1), 9473-9473 (2019-07-03)
Farmland bird populations have strongly declined across Europe over the last decades due to agriculture intensification, despite successive reforms of EU's Common Agricultural Policy (CAP). In parallel, CAP has led to a reduction of fallow land, a critical habitat for
R L Handy et al.
British journal of pharmacology, 119(2), 423-431 (1996-09-01)
1. The ability of a range of substituted imidazole compounds to inhibit mouse cerebellar neuronal nitric oxide synthase (nNOS), bovine aortic endothelial NOS (eNOS) and inducible NOS (iNOS) from lungs of endotoxin-pretreated rats was investigated. In each case the substrate
Vallo Volke et al.
Behavioural brain research, 140(1-2), 141-147 (2003-03-20)
Various inhibitors of nitric oxide synthase (NOS) have been shown to possess antidepressant- and anxiolytic-like properties in animal models. The aim of this study was to compare the behavioural effects of NOS inhibitor 7-nitroindazole (7-NI) with the more selective neuronal
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