T7165

Tyrphostin 23

≥98%

• Synonym(e): (3,4-Dihydroxybenzylidene)malononitrile, RG-50810
• Empirische Formel (Hill-System): C₁₀H₆N₂O₂
• CAS-Nummer: 118409-57-7
• Molekulargewicht: 186.17
• MDL-Nummer: MFCD00133899
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278041
• NACRES: NA.77

Eigenschaften

• Biologische Quelle: synthetic (organic)
• Assay: ≥98%
• Form: powder
• Wirksamkeit: 35 μM IC₅₀
• Löslichkeit: DMSO: soluble 50 mg/mL, clear, yellow to brownish-yellow
• Lagertemp.: 2-8°C
• SMILES String: Oc1ccc(cc1O)\C=C(\C#N)C#N
• InChI: 1S/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H
• InChIKey: VTJXFTPMFYAJJU-UHFFFAOYSA-N
• Angaben zum Gen: human ... CDK2(1017)

Beschreibung

Anwendung

Tyrphostin 23 can be used as a tyrosine kinase inhibitor for studying rat ghrelin-induced MAPK stimulation in GH3 cells[1]. Tyrphostin 23 has also been used to analyze its effects on secretoneurin (SN)-induced chemotaxis of neutrophils[2].

Biochem./physiol. Wirkung

Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain[3],[4].

Leistungsmerkmale und Vorteile

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Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)