Direkt zum Inhalt
Merck
Alle Fotos(2)

Dokumente

T6069

Sigma-Aldrich

Thio-TEPA

Synonym(e):

N,N′,N″-Triethylenethiophosphoramide, Thio-Tep, Thiofozil, Thiotef, Tio-tef, Tiofosfamid, Tiofosyl, Tiofozil, Tris(aziridinyl)phosphine sulfide

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Alle Fotos(2)

About This Item

Empirische Formel (Hill-System):
C6H12N3PS
CAS-Nummer:
52-24-4
Molekulargewicht:
189.22
EG-Nummer:
200-135-7
MDL-Nummer:
MFCD00145452
UNSPSC-Code:
51102829
PubChem Substanz-ID:
24900346
NACRES:
NA.85

Form

solid

Lagerbedingungen

(Keep container tightly closed in a dry and well-ventilated place.)

Farbe

white

Wirkungsspektrum von Antibiotika

neoplastics

Wirkungsweise

DNA synthesis | interferes

Lagertemp.

2-8°C

SMILES String

S=P(N1CC1)(N2CC2)N3CC3

InChI

1S/C6H12N3PS/c11-10(7-1-2-7,8-3-4-8)9-5-6-9/h1-6H2

InChIKey

FOCVUCIESVLUNU-UHFFFAOYSA-N

Suchen Sie nach ähnlichen Produkten? Aufrufen Leitfaden zum Produktvergleich

Verwandte Kategorien

Allgemeine Beschreibung

Chemical structure: aziridine

Anwendung

A polyfunctional alkylating agent

Biochem./physiol. Wirkung

The unstable nitrogen-carbon groups alkylate with DNA which causes irreversible DNA damage. They stop tumor growth by crosslinking guanine nucleobases in DNA double-helix strands, directly attacking DNA. The DNA strands are unable to uncoil and separate which halts cell division.

Hinweis zur Analyse

Solubility - freely soluble in water , in chloroform and in ethanol (96%)

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place.

Piktogramme

Skull and crossbonesHealth hazard
GHS06,GHS08

Signalwort

Danger

H-Sätze

H300,H350

Gefahreneinstufungen

Acute Tox. 2 Oral - Carc. 1B

Lagerklassenschlüssel

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Kunden haben sich ebenfalls angesehen

Slide 1 of 6

1 of 6

Azamulin ≥98% (HPLC)

Sigma-Aldrich

SML0485

Azamulin

Ticlopidin -hydrochlorid analytical standard, for drug analysis

Supelco

T6654

Ticlopidin -hydrochlorid

(+)-N-3-Benzyl Nirvanol ≥98% (HPLC), powder

Sigma-Aldrich

B8686

(+)-N-3-Benzyl Nirvanol

N-Tosylaziridin 98%

Sigma-Aldrich

712728

N-Tosylaziridin

Tetraethylenpentamin technical grade

Sigma-Aldrich

T11509

Tetraethylenpentamin

Gemfibrozil

Sigma-Aldrich

G9518

Gemfibrozil

Ki Woong Sung et al.
Neuro-oncology, 15(3), 352-359 (2012-12-22)
We assessed the feasibility and effectiveness of reduced-dose craniospinal (CS) radiotherapy (RT) followed by tandem high-dose chemotherapy and autologous stem cell transplantation (HDCT/autoSCT) in reducing late adverse effects without jeopardizing survival among children with high-risk medulloblastoma (MB). From October 2005
B Kasenda et al.
Annals of oncology : official journal of the European Society for Medical Oncology, 23(10), 2670-2675 (2012-04-05)
High-dose chemotherapy followed by autologous stem-cell transplantation (HCT-ASCT) is a promising approach in eligible patients with primary central nervous system lymphoma (PCNSL). We report long-term data of patients who were treated according to HCT-ASCT containing protocols. We analyzed survival and
Samuel A Bobholz et al.
Tomography (Ann Arbor, Mich.), 6(2), 160-169 (2020-06-18)
Magnetic resonance (MR)-derived radiomic features have shown substantial predictive utility in modeling different prognostic factors of glioblastoma and other brain cancers. However, the biological relationship underpinning these predictive models has been largely unstudied, and the generalizability of these models had
Anna Maria Raiola et al.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 19(1), 117-122 (2012-09-04)
Fifty patients with high-risk hematologic malignancies, underwent an unmanipulated haploidentical bone marrow transplantation (BMT), followed by posttransplantation high-dose cyclophosphamide (PT-CY): the myeloablative (MA) conditioning consisted of thiotepa, busulfan, fludarabine (n = 35), or total body irradiation (TBI), fludarabine (n =
Najeeb Ullah et al.
PloS one, 6(12), e27093-e27093 (2011-12-14)
Exposure to the chemotherapeutic alkylating agent thiotepa during brain development leads to neurological complications arising from neurodegeneration and irreversible damage to the developing central nerve system (CNS). Administration of single dose of thiotepa in 7-d postnatal (P7) rat triggers activation
Alle zugehörigen Dokumente anzeigen

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.