SRP6526

FTO human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

• Synonym(e): FATSO, Fat Mass and Obesity-associated Protein
• UNSPSC-Code: 12352200
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: human
• Rekombinant: expressed in E. coli
• Assay: ≥90% (SDS-PAGE)
• Form: liquid
• Mol-Gew.: ~65 kDa (Human FTO aa 2-505 is fused at the N-terminus to a His-tag.)
• Verpackung: pkg of 10 μg
• Konzentration: 0.2 mg/mL
• Verunreinigungen: <1 EU/μg endotoxin (LAL test)
• UniProt-Hinterlegungsnummer: Q9C0B1
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Angaben zum Gen: human ... FTO(79068)

Beschreibung

Allgemeine Beschreibung

FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse ‘fused toes′ mutation. An association between FTO genotype and type 2 diabetes has been confirmed. The presence of the FTO rs9939609 A-allele was found to be positively correlated with other symptoms of the metabolic syndrome, including higher fasting insulin, glucose, triglycerides, and lower HDL-cholesterol.

The fat mass and obesity-associated (FTO) gene is mapped to human chromosome 16q12.2.[1] The encoded protein is a nuclear protein and belongs to the AlkB-related non-haem iron- and 2-oxoglutarate-dependent dioxygenase family.[2]

Biochem./physiol. Wirkung

FTO (Fat mass-and obesity-associated gene) is the responsible gene for mouse ‘fused toes′ mutation. An association between FTO genotype and type 2 diabetes has been confirmed.[3] The presence of the FTO rs9939609 A-allele was found to be positively correlated with other symptoms of the metabolic syndrome,[4] including higher fasting insulin, glucose, triglycerides, and lower high-density lipoprotein (HDL)-cholesterol. FTO stimulates adipogenesis, tumorigenesis, and drug resistance of cancer cells. It does so by reducing the levels of messenger RNA N6-methyladenosine (m6A) of certain genes post-transcription. The FTO single-nucleotide polymorphisms (SNPs) are associated with elevated body mass and obesity in humans.[5]

Physikalische Form

0.2 mg/mL of 0.2 μm-filtered solution in 55 mM Tris-Cl, pH 8.2 containing 150 mM NaCl.

Sicherheitshinweise

• Lagerklassenschlüssel: 13 - Non Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable