SRP6284

Irisin human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

• Synonym(e): FNDC5 (cleaved), Fibronectin Type III Domain-containing Protein 5, Fibronectin Type III Repeat-containing Protein 2 (cleaved)
• UNSPSC-Code: 12352202

Eigenschaften

• Biologische Quelle: human
• Rekombinant: expressed in E. coli
• Assay: ≥95% (SDS-PAGE)
• Form: lyophilized powder
• Mol-Gew.: ~13 kDa
• Verpackung: pkg of 10 μg
• UniProt-Hinterlegungsnummer: Q8NAU1
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Angaben zum Gen: human ... FNDC5(252995)

Beschreibung

Allgemeine Beschreibung

Irisin is a recently described exercise-induced hormone secreted by skeletal muscle in mice and humans. Irisin is cleaved from the type I membrane protein FNDC5 (fibronectin type III domain containing 5).[1][2] FNDC5 is mainly expressed in the muscles. Low levels of the mRNA are also present in the kidney, liver and lung.[2] The gene FNDC5 is mapped to human chromosome 1p35.1.[3]

Biochem./physiol. Wirkung

Irisin activates beige fat cells (beige cells have a gene expression pattern distinct from either white or brown fat and are preferentially sensitive to the polypeptide hormone Irisin) and improves systemic metabolism by increasing energy expenditure.[1][2] It is mainly responsible for the conversion of white fat into brown fat. This conversion enhances metabolic uncoupling and caloric expenditure.[1] Irisin is always associated with beneficial responses of exercise on cellular metabolism.[2] In obese and type 2 diabetic patients, low levels of circulating irisin are characteristic of the adipose tissue and muscle.[4]

Physikalische Form

Lyophilized from PBS.

Rekonstituierung

Reconstitute to 0.1 mg/mL with 100μL sterile water.

Sicherheitshinweise

• Lagerklassenschlüssel: 13 - Non Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable