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SRP5075

Sigma-Aldrich

PTPN2, active, GST tagged human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution

Synonym(e):

PTPT, TCELLPTP, TCPTP

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About This Item

UNSPSC-Code:
12352200
NACRES:
NA.32

Rekombinant

expressed in E. coli

Assay

≥70% (SDS-PAGE)

Form

buffered aqueous glycerol solution

Spezifische Aktivität

6928-9372 nmol/min·mg

Mol-Gew.

~69 kDa

NCBI-Hinterlegungsnummer

NM_080422

Versandbedingung

dry ice

Lagertemp.

−70°C

Angaben zum Gen

human ... PTPN2(5771)

Allgemeine Beschreibung

Research Area: Cell Signaling
Protein tyrosine phosphatase, non-receptor type 2 (PTPN2), is one of the most abundant mammalian tyrosine phosphatase. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. By virtue of protein tyrosine phosphatase activity, PTPN2 is known to be a signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation involved in cell communication and signal transduction.

Biochem./physiol. Wirkung

Protein tyrosine phosphatase, non-receptor type 2 (PTPN2) regulates interferon signaling and the endoplasmic reticulum stress response in pancreatic β-cells during autoimmune diabetes. It serves as a crucial prognostic marker that influences the progression of pancreatic adenocarcinoma (PAAD) by activating the JAK-STAT signaling pathway. Silencing PTPN2 leads to a significant reduction in PAAD cell growth, migration, and invasion, while also triggering cell cycle arrest and apoptosis in PAAD cells.

Physikalische Form

Supplied in 20mM MOPS, pH 7.5, 50mM NaCl, 10mM glutathione, 0.25mM DTT, 0.1mM PMSF, 30% glycerol.

Angaben zur Herstellung

after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

PTPN2, A key predictor of prognosis for pancreatic adenocarcinoma, significantly regulates cell cycles, apoptosis, and metastasis
Kuang W, et al.
Frontiers in Immunology, 13, 805311-805311 (2022)
PTPN2 regulates the interferon signaling and endoplasmic reticulum stress response in pancreatic beta cells in autoimmune diabetes
Elvira B, et al.
Diabetes, 71(4), 653-668 (2022)
Tetsuya Yamamoto et al.
Biochemical and biophysical research communications, 297(4), 811-817 (2002-10-03)
In the previous study, we demonstrated that the nuclear isoform of T-cell protein-tyrosine phosphatase (TC-PTP) dephosphorylated and deactivated signal transducer and activator of transcription 5a (STAT5a) and STAT5b, thereby negatively regulating prolactin (PRL)-mediated signaling pathway. In this study, we examined
Sanjeev Gupta et al.
FEBS letters, 532(1-2), 61-66 (2002-12-03)
PTP-S2/TC45 is a nuclear protein tyrosine phosphatase, which induces p53-dependent apoptosis. Here we show that the p53 protein level increased in MCF-7 cells in response to PTP-S2 overexpression. PTP-S2-induced p53 protein was transcriptionally active and it could activate caspase-1 gene

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