Human Bromodomain containing 3, also known as BRD3 or RING3L (GenBank Accession No. NM_007371) amino-acids 306 – 417 with N-terminal HIS-tag, MW = 14.1 kDa, expressed in an E. coli expression system.
Molecular and cellular biology, 31(13), 2632-2640 (2011-05-11)
Recent data demonstrate that small synthetic compounds specifically targeting bromodomain proteins can modulate the expression of cancer-related or inflammatory genes. Although these studies have focused on the ability of bromodomains to recognize acetylated histones, it is increasingly becoming clear that
Proceedings of the National Academy of Sciences of the United States of America, 108(22), E159-E168 (2011-05-04)
Acetylation of histones triggers association with bromodomain-containing proteins that regulate diverse chromatin-related processes. Although acetylation of transcription factors has been appreciated for some time, the mechanistic consequences are less well understood. The hematopoietic transcription factor GATA1 is acetylated at conserved
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