Human Checkpoint kinase 2 (GenBank Accession No. NM_007194), full length with N-terminal HIS-tag, MW=91kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Anwendung
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
Central to the DNA damage response (DDR) is the highly conserved Mre11 complex consisting of Mre11, Rad50 and Nbs1. The Mre11 complex acts as a sensor of DNA double-strand breaks (DSBs) and regulates the signal transduction cascades that are triggered
The EMBO journal, 39(10), e103111-e103111 (2020-03-19)
The homeostatic link between oxidative stress and autophagy plays an important role in cellular responses to a wide variety of physiological and pathological conditions. However, the regulatory pathway and outcomes remain incompletely understood. Here, we show that reactive oxygen species
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