Human JMJD2D, also known as KDM4D (GenBank Accession No. NM_018039), amino-acids 2-354 with N-terminal GST tag, MW=67 kDa, expressed in a Baculovirus infected Sf9 cell expression system.
Anwendung
Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling.
International journal of oncology, 24(6), 1623-1628 (2004-05-13)
JMJD1 family genes, including JMJD1 (TSGA), TRIP8, and C5orf7 (5qNCA), encode nuclear proteins with Jumonji C (JmjC), TRI8H1 and TRI8H2 domains. Here, we identified JMJD2 family genes. Human genes corresponding to KIAA0677, KIAA0876, KIAA0780 and FLJ10251 cDNAs were designated JMJD2A
Biochemical and biophysical research communications, 353(4), 973-977 (2007-01-09)
JMJD2A-D belong to the JmjC domain-containing family of histone demethylases. JMJD2D is the most structurally divergent JMJD2 protein as it lacks the PHD and Tudor domains present in JMJD2A-C. Here, we systematically analyzed the histone demethylase specificity of JMJD2 proteins
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