SML3718

SIAIS630121

≥98% (HPLC)

• Synonym(e): (E)-N-(4-(1-(4-(4-(8-(2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oct-7-yn-1-yl)piperazin-1-yl)benzoyl)piperidin-4-yl)butyl)-3-(pyridin-3-yl)acrylamide
• Empirische Formel (Hill-System): C₄₉H₅₉N₇O₅
• Molekulargewicht: 826.04
• UNSPSC-Code: 51111800
• UNSPSC-Code: 12352200
• NACRES: NA.21

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear (Warmed)
• Lagertemp.: -10 to -25°C
• SMILES String: O=C(/C=C/C1=CN=CC=C1)NCCCCC2CCN(CC2)C(C3=CC=C(C=C3)N4CCN(CC4)CCCCCCC#CC5=CC=CC6=C5CN(C6=O)C7C(NC(CC7)=O)=O)=O
• InChI: 1S/C49H59N7O5/c57-45(22-16-38-12-10-26-50-35-38)51-27-7-6-11-37-24-29-55(30-25-37)48(60)40-17-19-41(20-18-40)54-33-31-53(32-34-54)28-8-4-2-1-3-5-13-39-14-9-15-42-43(39)36-56(49(42)61)44-21-23-46(58)52-47(44)59/h9-10,12,14-20,22,26,35,37,44H,1-4,6-8,11,21,
• InChIKey: JTTGVFCANBFLCE-CJLVFECKSA-N

Beschreibung

Biochem./physiol. Wirkung

Orally available, cell penetrant, potent and highly selective PROTAC that induces NAMPT degradation in several cancer cells lines

SIAIS630121 is an orally available, cell penetrant, potent and highly selective proteolysis-targeting chimera (PROTAC) that induces NAMPT (nicotinamide phosphoribosyltransferase) degradation in several cancer cells lines (SW620, HT29, and HCT116). It contains NAMPT inhibitor FK866 linked to cereblon (CRBN) ligand lenalidomide. SIAIS630121 exhibits rapid and potent degradation of iNAMPT and eNAMPT.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable