SML2681

cRIPGBM

≥98% (HPLC)

• Synonym(e): 1-Benzyl-3-(4-fluorobenzyl)-2-methyl-4,9-dioxo-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium chloride, RIPGBM proapoptic metabolite
• Empirische Formel (Hill-System): C₂₆H₂₀ClFN₂O₂
• CAS-Nummer: 2361988-77-2
• Molekulargewicht: 446.90
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: O=C1C2=C([N+](CC3=CC=C(F)C=C3)=C(C)N2CC4=CC=CC=C4)C(C5=C1C=CC=C5)=O.[Cl-]
• InChI: 1S/C26H20FN2O2.ClH/c1-17-28(15-18-7-3-2-4-8-18)23-24(29(17)16-19-11-13-20(27)14-12-19)26(31)22-10-6-5-9-21(22)25(23)30;/h2-14H,15-16H2,1H3;1H/q+1;/p-1
• InChIKey: IHNGETPFBJHWFE-UHFFFAOYSA-M

Beschreibung

Biochem./physiol. Wirkung

Apoptosis inducer that binds receptor-interacting protein kinase 2 (RIPK2, RIP2) and promotes the proapoptotic RIPK2/caspase-1 complex formation.

cRIPGBM is an apoptosis inducer (GBM-1/-5/-39 EC₅₀ = 63/95/290 nM; human neural progenitor cells (NPCs)/astrocytes/lung fibroblasts EC₅₀ = 190/710/960 nM) that binds receptor-interacting protein kinase 2 (RIPK2, RIP2) and promotes the formation of a proapoptotic RIPK2/caspase-1 complex. Cell type-selective metabolic redox conversion of RIPGBM to cRIPGBM in glioblastoma multiforme (GBM) cancer stem cells (CSCs) form the basis of selective GBM CSCs apoptosis induction by RIPGBM over non-GBM cultures.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable