SML2464

KRN2

≥98% (HPLC)

• Synonym(e): KRN2, 13-[(2-Fluorophenyl)methyl]-5,6-dihydro-9,10-dimethoxy-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium chloride
• Empirische Formel (Hill-System): C₂₇H₂₃FClNO₄
• CAS-Nummer: 248260-75-5
• Molekulargewicht: 479.93
• MDL-Nummer: MFCD31728343
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: faint yellow to dark orange
• Löslichkeit: H₂O: 2 mg/mL, clear (warmed)
• Lagertemp.: 2-8°C
• SMILES String: FC(C=CC=C1)=C1CC2=C([N+](CC3)=CC4=C2C=CC(OC)=C4OC)C5=C3C=C(OCO6)C6=C5.[Cl-]
• InChIKey: RPHFGOXVJGNJJH-UHFFFAOYSA-M

Beschreibung

Biochem./physiol. Wirkung

KRN2 is a specific and potent inhibitor of nuclear factor of activated T cells 5 (NFAT5) that inhibits formation of NF-κB p65-DNA complexes. KRN2 suppresses migration of Fibroblast-like synoviocytes stimulated with TGF-β. KRN2 ameliorates experimental arthritis in mice.

KRN2 or 13-(2-fluorobenzyl)-berberine is a berberine derivative that effectively blocks the invasiveness of fibroblast-like synoviocytes (FLS).[1] It is stable and orally bioavailable. It suppresses the production of proinflammatory cytokines to ameliorate arthritis severity.[2]

specific and potent inhibitor of nuclear factor of activated T cells 5 (NFAT5) that inhibits formation of NF-κB p65-DNA complexes

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable