SML1891

PK11007

≥98% (HPLC)

• Synonym(e): 5-Chloro-2-(methylsulfonyl)-4-pyrimidinecarboxylic acid
• Empirische Formel (Hill-System): C₆H₅ClN₂O₄S
• CAS-Nummer: 38275-34-2
• Molekulargewicht: 236.63
• MDL-Nummer: MFCD00507244
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: H₂O: 10 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: [S](=O)(=O)(C)c1nc(c(cn1)Cl)C(=O)O
• InChI: 1S/C6H5ClN2O4S/c1-14(12,13)6-8-2-3(7)4(9-6)5(10)11/h2H,1H3,(H,10,11)
• InChIKey: WZUPWJVRWIVWEF-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

PK11007 is a thiol-reactive anticancer agent that stabilizes wild type and mutant p53 through selective alkylation of two surface cysteines without interfering with its DNA binding.

PK11007 is a thiol-reactive anticancer agent that stabilizes wild type and mutant p53 through selective alkylation of two surface cysteines without interfering with its DNA binding. Additionally independently from p53, PK11007 impairs reactive oxygen species (ROS) detoxification in a number of mutant p53 cancer cells. PK11007 exhibits anticancer activity in number of cancer cell lines while shoving low cytotoxicity toward normal cells.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319
• P-Sätze: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable