SML1691

ZM323881 hydrochloride

≥98% (HPLC)

• Synonym(e): 5-((7-Benzyloxyquinazolin-4-yl)amino)-4-fluoro-2-methylphenol hydrochloride, ZM-323881 hydrochloride
• Empirische Formel (Hill-System): C₂₂H₁₈FN₃O₂ · HCl
• CAS-Nummer: 193000-39-4
• Molekulargewicht: 411.86
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: DMSO: 10 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: Fc1c(cc(c(c1)C)O)Nc2ncnc3c2ccc(c3)OCc4ccccc4.Cl
• InChI: 1S/C22H18FN3O2.ClH/c1-14-9-18(23)20(11-21(14)27)26-22-17-8-7-16(10-19(17)24-13-25-22)28-12-15-5-3-2-4-6-15;/h2-11,13,27H,12H2,1H3,(H,24,25,26);1H
• InChIKey: AVRHWGLIYGJSOD-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

ZM323881 is a selective inhibitor of VEGFR-2 with an IC₅₀ value of 2 nM. ZM323881 is selective for VEGFR-2 over VEGFR-1 and other receptor tyrosine kinases including PDGFRβ, FGFR1, EGFR and erbB2. ZM323881 inhibited VEGF-A-induced endothelial cell proliferation with an IC₅₀ value of 8 nM.

ZM323881 is a selective inhibitor of VEGFR-2.

ZM323881 is also known as (5‐{[7‐(benzyloxy) quinazolin‐4‐yl]amino}‐4‐fluoro‐2‐methylphenol).[1] It is capable of blocking the efflux function and altering breast cancer resistant protein (BCRP)-related multidrug resistance (MDR).[2]

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable