SML1513

SR1848

≥98% (HPLC)

• Synonym(e): 6-[4-(3-Chlorophenyl)-1-piperazinyl]-3-cyclohexyl-2,4(1H,3H)-pyrimidinedione, CDI 3238389, ML180
• Empirische Formel (Hill-System): C₂₀H₂₅ClN₄O₂
• CAS-Nummer: 863588-32-3
• Molekulargewicht: 388.89
• MDL-Nummer: MFCD05894342
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825930
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 5 mg/mL, clear (warmed)
• Lagertemp.: 2-8°C
• SMILES String: O=C(N(C1CCCCC1)C(N2)=O)C=C2N3CCN(C4=CC(Cl)=CC=C4)CC3
• InChI: 1S/C20H25ClN4O2/c21-15-5-4-8-17(13-15)23-9-11-24(12-10-23)18-14-19(26)25(20(27)22-18)16-6-2-1-3-7-16/h4-5,8,13-14,16H,1-3,6-7,9-12H2,(H,22,27)
• InChIKey: CHMQQIFPOIZPIJ-UHFFFAOYSA-N

Beschreibung

Anwendung

SR1848 has been used as a liver receptor homolog 1 (LRH-1) inhibitor to study the role of LRH-1 in the regulation of lipopolysaccharide (LPS)-induced proinflammatory cytokines in mice macrophage.[1] It has also been used as an LRH-1 inhibitor to study its effects on activation-induced Fas ligand (FasL) expression in the murine T-cell hybridoma cell line.[2]

Biochem./physiol. Wirkung

SR1848 is a cell penetrant and potent inhibitor of LRH-1.

SR1848 is a cell penetrant and potent inhibitor of orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2) that reduces the expression of CyclinD1 and E1, which results in inhibition of cell proliferation. SR1848 induces rapid translocation of nuclear LRH-1 to the cytoplasm.

The actions of SR1848 might contribute to anti-cancer functionality.[3]

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable