SML0999

ME0328

≥98% (HPLC)

• Synonym(e): (S)-3,4-Dihydro-4-oxo-N-(1-phenylethyl)-2-quinazolinepropanamide
• Empirische Formel (Hill-System): C₁₉H₁₉N₃O₂
• CAS-Nummer: 1445251-22-8
• Molekulargewicht: 321.37
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 10 mg/mL, clear
• Lagertemp.: room temp
• SMILES String: [nH]1c2c([c](nc1CCC(=O)N[C@@H](C)c3ccccc3)=O)cccc2
• InChI: 1S/C19H19N3O2/c1-13(14-7-3-2-4-8-14)20-18(23)12-11-17-21-16-10-6-5-9-15(16)19(24)22-17/h2-10,13H,11-12H2,1H3,(H,20,23)(H,21,22,24)/t13-/m0/s1
• InChIKey: QIHBWVVVRYYYRO-ZDUSSCGKSA-N

Beschreibung

Biochem./physiol. Wirkung

ME0328 is a selective inhibitor of ADP-ribosyltransferase-3/poly(ADP-ribose) polymerase-3 (ARTD3/PARP3), a PARP family member involved in DNA repair.

ME0328 is a selective inhibitor of ADP-ribosyltransferase-3/poly(ADP-ribose) polymerase-3 (ARTD3/PARP3), a PARP family member involved in DNA repair. ME0328 is the most potent isomer of the four ARTD3 ADP-ribosyltransferase inhibitors. ME0328 selectively inhibits ARTD3 (IC₅₀ of 890 nM) with weaker activity against ARTD1 and ARTD2 (IC₅₀ 6.3 and 10.8 μM, respectively), and no significant activity (IC₅₀ >30 μM) against any other ARTD enzyme. ME0328 appears to be the first selective inhibitor of ARTD3/PARP3.

Leistungsmerkmale und Vorteile

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Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable