SML0619

KG-548

≥97% (HPLC)

• Synonym(e): 5-[3,5-Bis(trifluoromethyl)phenyl]tetrazole
• Empirische Formel (Hill-System): C₉H₄F₆N₄
• CAS-Nummer: 175205-09-1
• Molekulargewicht: 282.15
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥97% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 20 mg/mL, clear
• Lagertemp.: 2-8°C
• InChI: 1S/C9H4F6N4/c10-8(11,12)5-1-4(7-16-18-19-17-7)2-6(3-5)9(13,14)15/h1-3H,(H,16,17,18,19)
• InChIKey: KKJFZIQEWZVVIV-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

KG-548 is an inhibitor of the hypoxia signaling transcription factor complex.

KG-548 is an inhibitor of the hypoxia signaling transcription factor complex. Hypoxia inducible factor (HIF) is a heterodimer of two bHLH-PAS (basic Helix Loop Helix - Per-ARNT-Sim) subunits, including a HIF-α paralog (HIF-1α, -2α, -3α) and aryl hydrocarbon receptor nuclear translocator (ARNT, also known as HIF-β. KG-548 selectively binds within the ARNT PAS domain of the ARNT subunit of the HIF activator that recruits TACC3 (Transforming Acidic Coiled Coil Containing Protein 3) coactivator, competing with TACC3 for binding to the ARNT PAS-B domain and thus acting as as an ARNT/TACC3 disruptor.

Sicherheitshinweise

• Piktogramme: GHS06
• Signalwort: Danger
• H-Sätze: H301,H315,H319,H335
• P-Sätze: P261 - P264 - P270 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3