SML0556

LY344864 hydrochloride

≥98% (HPLC)

• Synonym(e): N-[(3R)-3-(Dimethylamino)-2,3,4,9-tetrahydro-1H-carbazol-6-yl]-4-fluoro-benzamide hydrochloride
• Empirische Formel (Hill-System): C₂₁H₂₂FN₃O · HCl
• CAS-Nummer: 1217756-94-9
• Molekulargewicht: 387.88
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: H₂O: 10 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: Fc1ccc(cc1)C(=O)Nc2cc3c([nH]c4c3C[C@@H](CC4)N(C)C)cc2.Cl
• InChI: 1S/C21H22FN3O.ClH/c1-25(2)16-8-10-20-18(12-16)17-11-15(7-9-19(17)24-20)23-21(26)13-3-5-14(22)6-4-13;/h3-7,9,11,16,24H,8,10,12H2,1-2H3,(H,23,26);1H/t16-;/m1./s1
• InChIKey: OKUHLSYESBLBCP-PKLMIRHRSA-N

Beschreibung

Biochem./physiol. Wirkung

LY344864 hydrochloride is a potent and selective 5-HT1F receptor agonist.

LY344864 hydrochloride is a potent and selective 5-HT1F receptor agonist. It has an EC₅₀ of 3 nM, and displays > 80-fold selectivity over other 5-HT receptors

LY344864 might be useful in the treatment approach for migraine. LY344864 is found to prevent the extravasation of dura protein and reduce c-fos like immunoreactions induced by capsaicin.[1]

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable