SML0440

Spautin-1

≥98% (HPLC)

• Synonym(e): 6-Fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine, C43
• Empirische Formel (Hill-System): C₁₅H₁₁F₂N₃
• CAS-Nummer: 1262888-28-7
• Molekulargewicht: 271.26
• MDL-Nummer: MFCD16962292
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329824722
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 15 mg/mL (clear solution)
• Lagertemp.: 2-8°C
• SMILES String: FC1=CC=C(C=C1)CNC2=C3C=C(F)C=CC3=NC=N2
• InChI: 1S/C15H11F2N3/c16-11-3-1-10(2-4-11)8-18-15-13-7-12(17)5-6-14(13)19-9-20-15/h1-7,9H,8H2,(H,18,19,20)
• InChIKey: AWIVHRPYFSSVOG-UHFFFAOYSA-N

Beschreibung

Anwendung

Spautin-1 has been used as an autophagy inhibitor:

• to study its effects on vascular, glial, and neuronal alterations in the oxygen-induced retinopathy mouse model[1]
• to evaluate its pre-treatment effect on the response of canine osteosarcoma cells to doxorubicin[2]
• to study its effects on the production of interleukin (IL)-6 by oxidatively stressed dendritic cells (OS-DCs) in Luminex assay[3]

Biochem./physiol. Wirkung

Spautin-1 inhibits the activity of two ubiquitin-specific peptidases, USP10 and USP13, causing an increase in proteasomal degradation of class III PI3 kinase complexes, which have been shown to regulate autophagy.

Spautin-1 is an inhibitor of autophagy.

Specific and potent autophagy inhibitor-1 (Spautin-1) is a small molecule, which can inhibit autophagy and induce cancer cell death. It inhibits autophagy by degrading beclin-1. Spautin-1 augments the efficiency of radiation therapy and chemotherapy in various human cancer cell lines.[2]

Sicherheitshinweise

• Piktogramme: GHS05,GHS07
• Signalwort: Danger
• H-Sätze: H302,H318
• P-Sätze: P280 - P301 + P312 + P330 - P305 + P351 + P338 + P310
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Dam. 1
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable