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SML0438

Sigma-Aldrich

Miboleron

≥98% (HPLC)

Synonym(e):

(7α,17β)-17-Hydroxy-7,17-dimethylestr-4-en-3-on, 7α,17α-Dimethyl-19-nortestosteron

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About This Item

Empirische Formel (Hill-System):
C20H30O2
CAS-Nummer:
3704-09-4
Molekulargewicht:
302.45
EG-Nummer:
223-046-5
UNSPSC-Code:
51111800
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

powder

Arzneimittelkontrolle

USDEA Schedule IIIN; regulated under CDSA - not available from Sigma-Aldrich Canada

Farbe

white to beige

Löslichkeit

DMSO: 5 mg/mL, clear (warmed)

Lagertemp.

2-8°C

InChI

1S/C20H30O2/c1-12-10-13-11-14(21)4-5-15(13)16-6-8-19(2)17(18(12)16)7-9-20(19,3)22/h11-12,15-18,22H,4-10H2,1-3H3/t12-,15+,16-,17+,18-,19+,20+/m1/s1

InChIKey

PTQMMNYJKCSPET-OMHQDGTGSA-N

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Allgemeine Beschreibung

The synthetic androgen mibolerone (7α,17α dimethyl-19-nortestosterone) is an androgenic steroid.

Biochem./physiol. Wirkung

Mibolerone is a synthetic anabolic steroid with a similar profile of activity as R1881 (Metribolone) with a higher affinity (Kd = 1.5 nM) for the androgen receptor in human prostate tissue than R1881 (Kd = 2.3 nM).
The synthetic androgen mibolerone (7α,17α dimethyl-19-nortestosterone) reversibly blocks the multiplication of LNCaP (human prostate carcinoma cell line) cells. In prostate, liver, and cultured cells, it serves as an efficient radioactive ligand for the quantitation and characterization of androgen receptors.

Piktogramme

Health hazard
GHS08

Signalwort

Danger

H-Sätze

H360

Gefahreneinstufungen

Repr. 1B

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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The use of radioactive 7α,17α?dimethyl?19?nortestosterone (mibolerone) in the assay of androgen receptors.
Schilling K and Liao S
Prostate, 5(6), 581-588 (1984)
Wayne Balkan et al.
Biochemical and biophysical research communications, 328(3), 783-789 (2005-02-08)
Despite their clinical importance for skeletal growth and homeostasis, the actions of androgens on osteoblastic cells are not well understood. MC3T3-E1 cells, a nontransformed murine preosteoblastic cell line, that traverse the stages of osteoblastic differentiation within 30 days in vitro
Saunders Handbook of Veterinary Drugs: Small and Large Animal (2015)
Eugene Bratoeff et al.
The Journal of steroid biochemistry and molecular biology, 107(1-2), 48-56 (2007-07-17)
In order to study the biological activity of the two novel steroidal carbamates derivatives: 8a and 8b, we determined the concentration of both compounds that inhibit the 50% of the activity of human prostate 5alpha-reductase enzyme, as well as the
Elisa J Cops et al.
The Journal of steroid biochemistry and molecular biology, 110(3-5), 236-243 (2008-06-03)
Androgen signaling, mediated by the androgen receptor (AR), is a critical factor influencing growth of normal and malignant breast cells. Given the increasing use of exogenous androgens in women, a better understanding of androgen action in the breast is essential.
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