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SML0321

Sigma-Aldrich

Cyamemazine

≥98% (HPLC)

Synonym(e):

10-[3-(Dimethylamino)-2-methylpropyl]-10H-phenothiazine-2-carbonitrile, 7204 R. E., 7204 RP, Ciamatil, Cianatil, Cyamemazin, R.P. 7204, TH 2602

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94,50 €
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10 MG
94,50 €
50 MG
536,00 €

About This Item

Empirische Formel (Hill-System):
C19H21N3S
CAS-Nummer:
3546-03-0
Molekulargewicht:
323.46
EG-Nummer:
222-594-2
MDL-Nummer:
MFCD00868180
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329825326
NACRES:
NA.77

94,50 €

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Versandbereit am07. April 2025Details

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Assay

≥98% (HPLC)

Form

powder

Farbe

light yellow to yellow-green

Löslichkeit

DMSO: ≥5 mg/mL

Lagertemp.

2-8°C

SMILES String

CC(CN(C)C)CN1c2ccccc2Sc3ccc(cc13)C#N

InChI

1S/C19H21N3S/c1-14(12-21(2)3)13-22-16-6-4-5-7-18(16)23-19-9-8-15(11-20)10-17(19)22/h4-10,14H,12-13H2,1-3H3

InChIKey

SLFGIOIONGJGRT-UHFFFAOYSA-N

Anwendung

Cyamemazine has been used as an internal standard and antipsychotic drug to spike plasma samples in mass spectrometry studies.[1] It has also been used as an analytical standard in gas chromatography-tandem mass spectroscopic (GC-MS/MS) analysis.[2]

Biochem./physiol. Wirkung

Cyamemazine belongs to the class of phenothiazine drugs. It is known to treat severe depression, schizophrenia and bipolar disorder.[3]
Cyamemazine is a potent antagonist of 5-HT2C and 5-HT3 receptors with antipsychotic and anxiolytic properties.
Cyamemazine is a potent antagonist of 5-HT2C and 5-HT3 receptors.

Piktogramme

Environment
GHS09

Signalwort

Warning

H-Sätze

H410

Gefahreneinstufungen

Aquatic Acute 1 - Aquatic Chronic 1

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
114M4753V
042M4722V

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Die Dokumentenbibliothek aufrufen

Michel Bourin et al.
CNS drug reviews, 10(3), 219-229 (2004-10-20)
Several studies have suggested that the antipsychotic compound, cyamemazine, possesses anxiolytic properties in humans. The original pharmacological profile of cyamemazine (D(2), 5-HT(2A), 5-HT(2C), and 5-HT(3) receptor antagonist), which was established by binding, microdialysis and behavioral studies, is consistent with these
Sébastien Duband et al.
Forensic science international, 214(1-3), e26-e29 (2011-08-16)
Forensic pathologists are sometimes confronted with microscopic foreign bodies mixed in with soft tissues surrounding wounds and which are thus difficult to identify. This identification, however, could be primordial in investigating a crime and in determining the weapon used. A
Gurmit Singh et al.
Bioorganic & medicinal chemistry letters, 22(6), 2160-2162 (2012-03-01)
A modified Polonovski reaction has been employed to obtain the N-demethylated metabolite of the neuroleptic drug cyamemazine. The synthesis involves N-oxide formation, isolation of the corresponding N-oxide, and a FeSO(4)·7H(2)O mediated Polonovski reaction to afford the desired monodesmethyl cyamemazine. In
Paula Proença et al.
Journal of analytical toxicology, 44(8), 915-922 (2020-08-12)
Antipsychotic drugs (AP) are widely prescribed for the treatment of schizophrenia and psychosis. The pharmacological treatment of schizophrenia is often performed with the simultaneous use of two or more antipsychotic agents to achieve the desired control of psychotic symptoms Available
Amine Benyamina et al.
European journal of pharmacology, 578(2-3), 142-147 (2007-10-16)
Animal and human pharmacological studies indicate that the antipsychotic action of cyamemazine results from blockade of dopamine D(2) receptors, its anxiolytic properties from serotonin 5-HT(2C) receptor antagonism and the low incidence of extrapyramidal side effects from a potent 5-HT(2A) receptor
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