SML0213

MC2050 hydrate

≥98% (HPLC)

• Synonym(e): 2-[2-(4-(2-pyridyl)-1-piperazinyl)ethylsulfanyl]-3H-quinazolin-4-one dihydrochloride hydrate
• Empirische Formel (Hill-System): C₁₉H₂₁N₅OS·2HCl · xH₂O
• Molekulargewicht: 440.39 (anhydrous basis)
• MDL-Nummer: MFCD21608523
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825234
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: H₂O: ≥5 mg/mL at warmed to 60 °C
• Lagertemp.: 2-8°C
• SMILES String: O.Cl.Cl.O=C1NC(SCCN2CCN(CC2)c3ccccn3)=Nc4ccccc14
• InChI: 1S/C19H21N5OS.2ClH.H2O/c25-18-15-5-1-2-6-16(15)21-19(22-18)26-14-13-23-9-11-24(12-10-23)17-7-3-4-8-20-17;;;/h1-8H,9-14H2,(H,21,22,25);2*1H;1H2
• InChIKey: LMZZPRHHBPFDGE-UHFFFAOYSA-N

Beschreibung

Anwendung

MC2050 hydrate may be used in cell signaling studies.

Biochem./physiol. Wirkung

MC2050 is a PARP-1 inhibitor

MC2050 is a water-soluble PARP-1 inhibitor. The IC₅₀ for inhibition of PARP-1 activity is 119 nM, compared to 1.8 μM for PARP-2. MC2050 inhibits apoptosis and blocks poly ADP-ribosylation of histone H1 in hydrogen peroxide treated SH-SY5Y neuroblastoma cells.

Leistungsmerkmale und Vorteile

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable