SML0022

IMB-10

≥98% (HPLC)

• Synonym(e): 3-(2-methylphenyl)-5-(3-phenyl-2-propen-1-ylidene)-2-thioxo-4-thiazolidinone
• Empirische Formel (Hill-System): C₁₉H₁₅NOS₂
• CAS-Nummer: 307525-40-2
• Molekulargewicht: 337.46
• MDL-Nummer: MFCD20134199
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329825094
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: yellow
• Löslichkeit: DMSO: ≥25 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: Cc1ccccc1N2C(=S)S\C(=C\C=C\c3ccccc3)C2=O
• InChI: 1S/C19H15NOS2/c1-14-8-5-6-12-16(14)20-18(21)17(23-19(20)22)13-7-11-15-9-3-2-4-10-15/h2-13H,1H3/b11-7+,17-13+
• InChIKey: UYZLENPCNZVWQZ-QHMSGILQSA-N

Beschreibung

Anwendung

IMB-10 may be used to study integrin-mediated signaling in tumor cells.

Biochem./physiol. Wirkung

IMB-10 is a ligand for the αMβ2 integrin that stabilizes the binding of the integrin to endogenous ligands such as proMMP-9 and fibrinogen. IMB-10 blocks migration of lymphocyte cell lines and inhibits leukocyte infiltration in a murine thioglycolate-induced peritonitis.

IMB-10 is a thioxothiazolidine compound that inhibits the infiltration of leukocytes to the site of tumor and blocks the invasion of HSC-3 carcinoma. It modulates the host inflammatory responses and tumor progression.[1]

Stabilizing Ligand of αMβ2 integrin

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3