SMB01050

Licochalcone B

≥85% (LC/MS-ELSD)

• Synonym(e): (E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one, 3,4,4′-trihydroxy-2-methoxychalcone
• Empirische Formel (Hill-System): C₁₆H₁₄O₅
• CAS-Nummer: 58749-23-8
• Molekulargewicht: 286.28
• MDL-Nummer: MFCD20527294
• UNSPSC-Code: 12352205
• NACRES: NA.25

Eigenschaften

• Biologische Quelle: plant
• Assay: ≥85% (LC/MS-ELSD)
• Form: solid
• Mol-Gew.: 286.28
• Löslichkeit: water: slightly soluble
• Anwendung(en): metabolomics; vitamins, nutraceuticals, and natural products
• Lagertemp.: −20°C
• SMILES String: O(C)c1c(c(ccc1\C=C\C(=O)c2ccc(cc2)O)O)O
• InChI: 1S/C16H14O5/c1-21-16-11(5-9-14(19)15(16)20)4-8-13(18)10-2-6-12(17)7-3-10/h2-9,17,19-20H,1H3/b8-4+
• InChIKey: DRDRYGIIYOPBBZ-XBXARRHUSA-N

Beschreibung

Allgemeine Beschreibung

Licochalcone B is a prenylated flavonoid classified within the group of retrochalcones. This bioactive natural compound is commonly sourced from Glycyrrhiza species (G. glabra, G. uralensis, G. inflata, and G. aspera) plants. Existing research indicates that this plant-derived metabolite possesses a wide array of biological activities, including antibacterial, cardioprotective, anticancer, antioxidant, antiapoptotic, neuroprotective and anti-inflammatory properties.

Anwendung

It is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.

Biochem./physiol. Wirkung

According to the existing research, Licochalcone B exerts its effects through multiple pathways, making it a versatile candidate for various therapeutic applications. It effectively combats inflammation by inhibiting NF-κB activation induced by LPS, leading to reduced production of NO, TNFα, and MCP-1. For bladder cancer, Licochalcone B demonstrates its potential by inducing S phase arrest, modulating cell cycle-related proteins, suppressing anti-apoptotic factors, and activating caspase-3. These actions collectively limit tumor growth in vivo, suggesting its utility in both bladder cancer therapy and prevention. Furthermore, Licochalcone B showcases robust antioxidant capabilities, successfully mitigating lipid peroxidation and lowering ROS production. It also exhibits anti-inflammatory properties by decreasing the release of NO, IL-6, and PGE2 in response to LPS. Furthermore, Licochalcone B emerges as a promising candidate for Alzheimer′s disease treatment, effectively preventing Aβ42 aggregation, chelating metal ions, and providing neuroprotection.

Leistungsmerkmale und Vorteile

• High quality compound suitable for multiple research applications
• Compatible with HPLC and mass spectrometry techniques

Sonstige Hinweise

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Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable