SAB4502964

Anti-Tyrosine Hydroxylase, N-Terminal antibody produced in rabbit

affinity isolated antibody

• Synonym(e): TH isoform 3, TH isoform a, TH-4, TY3H, TYH
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen 58 kDa
• Speziesreaktivität: mouse, rat, human
• Konzentration: ~1 mg/mL
• Methode(n): ELISA: 1:10000; immunofluorescence: 1:100-1:500; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• NCBI-Hinterlegungsnummer: P07101
• UniProt-Hinterlegungsnummer: P07101
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... TH(7054)

Beschreibung

Allgemeine Beschreibung

Anti-Tyrosine Hydroxylase Antibody detects endogenous levels of total Tyrosine Hydroxylase protein.

The TH (tyrosine Hydroxylase) gene codes for a homotetramer that contains catalytic, regulatory, and tetramerization domains in each of its subunits.

Immunogen

The antiserum was produced against synthesized peptide derived from human Tyrosine Hydroxylase.

Immunogen Range: 10-59

Biochem./physiol. Wirkung

The conversion of l-tyrosine into l-DOPA is catalyzed by tyrosine hydroxylase (TH), which is the rate-limiting step in the in the synthesis of catecholamines such as dopamine and also other necessary hormones and neuromodulators. TH enzyme deficiency results in low levels of dopamine, which is characterised in Parkinson′s disease.

Leistungsmerkmale und Vorteile

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Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: nwg
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable