SAB4500094

Anti-YAP antibody produced in rabbit

affinity isolated antibody

• Synonym(e): 65 kDa Yes-associated protein, YAP1, YAP65
• MDL-Nummer: MFCD04118707
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 100
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous solution
• Mol-Gew.: antigen 48 kDa
• Speziesreaktivität: mouse, rat, human
• Konzentration: ~1 mg/mL
• Methode(n): ELISA: 1:1000; western blot: 1:500-1:1000
• NCBI-Hinterlegungsnummer: P46937
• UniProt-Hinterlegungsnummer: P46937
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: human ... YAP1(10413)

Beschreibung

Allgemeine Beschreibung

Anti-YAP Antibody detects endogenous levels of total YAP protein.

Yes associated protein (YAP) is a 65kDa proline-rich phosphoprotein. It is encoded by the gene mapped to human chromosome 11q22.1. The encoded protein is characterized with a WW domain, a PDZ interaction motif, an SH3 binding motif and a coiled-coil domain.

Immunogen

The antiserum was produced against synthesized peptide derived from human YAP.

Immunogen Range: 93-142

Biochem./physiol. Wirkung

Yes associated protein (YAP) serves as a potent mechanosensitive transcriptional activator. It plays a vital role in regulation of cancer, regeneration and organ size. Overexpression of the gene contributes to tumorigenesis in breast and liver cancers. In addition, it also promotes gallbladder cancer (GBC) cell growth via activating AXL receptor tyrosine kinase/mitogen-activated protein kinase (MAPK) pathway. Thus, it acts as a potent biomarker and therapeutic target for various cancers including, GBC and breast cancer.

Leistungsmerkmale und Vorteile

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Physikalische Form

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: nwg
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable