SAB4200829

Anti-Aflatoxin B1-Peroxidase antibody produced in rabbit

IgG fraction of antiserum

• Synonym(e): Anti-Aflatoxin B1-HRP
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Antikörperform: IgG fraction of antiserum
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: lyophilized powder
• Speziesreaktivität: Aspergillus parasiticus, Aspergillus flavus
• Methode(n): direct ELISA: 1:2,000-1:4,000 (recommended using 1 μg/ml Aflatoxin B1-BSA conjugate for coating.)
• Versandbedingung: dry ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified

Beschreibung

Allgemeine Beschreibung

Aflatoxins are a group of natural fungal metabolites synthesized by Aspergillus flavus and Aspergillus parasiticus, which can be found as toxins (mycotoxins) contaminants in human and animal food products. Aflatoxin B1 is the most abundant and significant member of the group also including B2, B2a, G1, G2a, M1, M2, P1, Q1, aflatoxicol I (natural isomer), aflatoxicol II (unnatural isomer), tetrahydrodeoxy aflatoxin B1 and the unstable reactive B1 (8,9)-epoxide. Aflatoxin B1 is activated by cytochrome P450 proteins, a family of liver abundant enzymes that converts the Aflatoxin into mutagenic and carcinogenic intermediates.
The ability of aflatoxin B1 and its metabolites to act as a potent carcinogen, mutagen, and teratogen, in addition to its toxicity is well known. Thus, aflatoxins have been implicated in human hepatocellular carcinoma, outbreaks of aflatoxicosis, Rey′s syndrome, chronic hepatitis and increased mortality from infection in animal husbandry. Humans and animals may be exposed to aflatoxins by consuming aflatoxins containing food products that have been directly contaminated by fungal strains during growth, harvest, or storage. Many grains and food ingredients including corn, peanuts, tree nuts, cottonseed, cereal crops, beans, cassava, milo, sorghum, copra, rice, dried fish, and beer have been found to be contaminated with aflatoxins due to natural invasion by molds before and during harvest, or because of improper storage. Thus consumers may be exposed to aflatoxins either directly by eating contaminated grains or nuts, or indirectly via animal tissues (meat) or animal products (milk) containing aflatoxins. The aflatoxins are increasingly recognized as a serious health risk to humans and animals alike. Consequently, a suitable analytical method for the detection of these toxins is required for effective food and feed safety-monitoring programs worldwide.

Immunogen

Aflatoxin B1-KLH

Anwendung

The antibody may be used in various immunochemical techniques including ELISA.

Physikalische Form

Supplied as a lyophilized powder.

Sonstige Hinweise

In order to obtain best results in different techniques and preparations we recommend determining optimal working concentration by titration test.

Haftungsausschluss

For U.S. Customers: Contains mercury; Do not place in trash - dispose according to local, state, or federal laws.

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable