GATA binding protein 1 (GATA1) is a key hematopoietic transcription factor. It is part of the GATA transcription factor family and the gene encoding it is localized on human chromosome Xp11.23.
Immunogen
Peptide with sequence C-DAEAYRHSPVFQ from the internal region of the protein sequence according to NP_002040.1.
Biochem./physiol. Wirkung
GATA binding protein 1 (GATA1) plays a crucial role in erythroid and megakaryocyte differentiation and proliferation. It modulates the expression of genes and acts as an E-cadherin repressor. Mutations in the GATA1 gene have been linked to transient abnormal myelopoiesis (TAM) and myeloid leukemia of DS (ML-DS). The protein has anti-apoptotic functions in breast cancer.
Leistungsmerkmale und Vorteile
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Physikalische Form
Supplied at 0.5 mg/mL in Tris saline with 0.02% sodium azide and 0.5% bovine serum albumin.
Human erythropoiesis serves as a paradigm of physiologic cellular differentiation. This process is also of considerable interest for better understanding anemias and identifying new therapies. Here, we apply deep transcriptomic and accessible chromatin profiling to characterize a faithful ex vivo human erythroid
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