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S7900

Sigma-Aldrich

Saponin aus Quillaja Rinde

Sapogenin content ≥10 %

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About This Item

CAS-Nummer:
8047-15-2
EG-Nummer:
232-462-6
MDL-Nummer:
MFCD00081981
UNSPSC-Code:
12161902
NACRES:
NA.32

Beschreibung

non-ionic

Zusammensetzung

Sapogenin content, ≥10%

Methode(n)

HPLC: suitable
protein quantification: suitable

Sulfatasche

<20%

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Allgemeine Beschreibung

Saponins are natural steroidal glycoside (terpenes).

Anwendung

Saponin from Quillaja bark has been used:
  • to stain CD4+ and CD8+ T-cells
  • to lyse trophozoite-infected red blood cells
  • in immunohistochemical staining

Biochem./physiol. Wirkung

Saponins are associated with many biological and pharmacological activities. It is known to stimulate immune response in mammals. Hence it is used as vaccine adjuvants. Saponins possesses antiviral, antifungal, antitumor, anti-inflammatory, hypoglycemic and hypocholesterolemic effects.
Saponins solubilize the low density lipoprotein (LDL) fraction of cholesterol in micelles, thus lowering their concentration. Saponin from Quillaja bark is used as a flavoring agent in food and beverages. This saponin has been shown to enhance immune-cell proliferation in vitro.
Potent hemolytic when injected i.v.; surfactant that enhances penetration of proteins and other macromolecules through cell membranes; it also has been used as an adjuvant for vaccines.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H319,H335

Gefahreneinstufungen

Eye Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

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Joo Young Park et al.
Journal of hazardous materials, 163(2-3), 761-767 (2008-08-12)
The applicability of microbubble suspension made of saponin as a biodegradation-enhancing carrier where oxygen and pollutant-degraders are limited was studied. The saponin-microbubble suspension was used to deliver phenanthrene-degrading bacteria, inorganic nutrients, and oxygen. Bench-scale study was carried out to determine
Samantha Reiss et al.
PloS one, 12(10), e0186998-e0186998 (2017-10-25)
The identification and study of antigen-specific CD4 T cells, both in peripheral blood and in tissues, is key for a broad range of immunological research, including vaccine responses and infectious diseases. Detection of these cells is hampered by both their
Xiaogang Jiang et al.
Environmental pollution (Barking, Essex : 1987), 236, 416-424 (2018-02-08)
Saponin-rich extracts from Quillaja saponaria and Chenopodium quinoa have been registered by US EPA as active ingredients in biopesticides, and extract from tea seed powder, Camellia oleifera has been proposed for biocidal use. If saponin-rich biopesticides are efficient against pests
Adjuvant effects of saponins on animal immune responses.
Rajput ZI
Journal of Zhejiang University. Science. B, 8(3), 153-161 (2007)
Effect of testosterone on insulin stimulated IRS1 Ser phosphorylation in primary rat myotubes--a potential model for PCOS-related insulin resistance.
Allemand MC
PLoS ONE, 4(1), e4274-e4274 (2009)
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