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S3065

Sigma-Aldrich

SC 19220

≥98% (HPLC), solid

Synonym(e):

2-Acetylhydrazide 10(11H)-carboxylic acid, 8-Chloro-dibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid

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10 MG
144,00 €

About This Item

Empirische Formel (Hill-System):
C16H14N3O3Cl
CAS-Nummer:
19395-87-0
Molekulargewicht:
331.75
MDL-Nummer:
MFCD02259329
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24278701
NACRES:
NA.77

144,00 €

Versandbereit am07. April 2025Details

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Assay

≥98% (HPLC)

Form

solid

Farbe

white

mp (Schmelzpunkt)

190-191 °C (lit.)

Löslichkeit

DMSO: soluble 10 mg/mL
H2O: insoluble

SMILES String

CC(=O)NNC(=O)N1Cc2ccccc2Oc3ccc(Cl)cc13

InChI

1S/C16H14ClN3O3/c1-10(21)18-19-16(22)20-9-11-4-2-3-5-14(11)23-15-7-6-12(17)8-13(15)20/h2-8H,9H2,1H3,(H,18,21)(H,19,22)

InChIKey

KNURFLJTOUGOOQ-UHFFFAOYSA-N

Angaben zum Gen

human ... PTGER1(5731)
rat ... Ptger1(25637)

Anwendung

SC 19220 was used to study the role of prostaglandin E2 in oxygen-glucose deprivation-induced neurotoxicity and preconditioning-induced neuroprotection in rat cortical cultures.[1]

Biochem./physiol. Wirkung

EP1 Prostanoid receptor antagonist
SC 19220 is a competitive antagonist of prostaglandin E receptors. It competes with PGE2 in regulating vesicourethral motility and increases the bladder capacity of rats.[2] It inhibits the contraction of smooth muscles in response to prostaglandins E2 and F2α.[3] SC 19220 also inhibits the formation of osteoclasts induced by vitamin D3, parathyroid hormone, IL-11 and IL-6.[4]

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
125K4609V
125K46093
125K46092
125K46091

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L Walch et al.
British journal of pharmacology, 134(8), 1671-1678 (2001-12-12)
1. To characterize the prostanoid receptors (TP, FP, EP(1) and/or EP(3)) involved in the vasoconstriction of human pulmonary veins, isolated venous preparations were challenged with different prostanoid-receptor agonists in the absence or presence of selective antagonists. 2. The stable thromboxane
K Oka et al.
The American journal of physiology, 275(6 Pt 2), R1762-R1765 (1998-12-09)
We have previously reported that central injection of PGE2 induces hyperthermia through its actions on EP1 receptors in rats. Because the increase in local synthesis of PGE2 is assumed to be a necessary process in a fever caused by central
S Santangelo et al.
The Journal of trauma, 48(5), 826-830 (2000-05-24)
Although prostaglandin E2 (PGE2) has been shown to be immunosuppressive, its role in the development of specific bone marrow myeloid lineages after thermal injury and sepsis has yet to be elucidated. The purpose of this study was to demonstrate that
J B Farmer et al.
British journal of pharmacology, 52(4), 559-565 (1974-12-01)
1 The effects of the prostaglandin synthetase inhibitor, indomethacin and the prostaglandin antagonist SC-19220 (1-acetyl-2-[8-chloro-10,11-dihydrodibenz (b,f) (1,4)oxazepine-10-carbonyl] hydrazine), were examined on the tone of the guinea-pig isolated tracheal preparation and on the responses of the preparation to prostaglandin F(2alpha), arachidonic
Micaela Zonta et al.
The Journal of physiology, 553(Pt 2), 407-414 (2003-09-23)
The synaptic release of glutamate evokes in astrocytes periodic increases in [Ca2+]i, due to the activation of metabotropic glutamate receptors (mGluRs). The frequency of these [Ca2+]i oscillations is controlled by the level of neuronal activity, indicating that they represent a
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