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S1563

Sigma-Aldrich

SKF-86466 hydrochloride

solid, ≥98% (HPLC)

Synonym(e):

6-Chloro-2,3,4,5-tetrahydro-3-methyl-1H-3-benzazepine hydrochloride

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About This Item

Lineare Formel:
C11H14ClN·HCl
CAS-Nummer:
86129-54-6
Molekulargewicht:
232.15
MDL-Nummer:
MFCD03453012
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24278695

Assay

≥98% (HPLC)

Form

solid

Farbe

white

Löslichkeit

H2O: 24 mg/mL

SMILES String

Cl.CN1CCc2cccc(Cl)c2CC1

InChI

1S/C11H14ClN.ClH/c1-13-7-5-9-3-2-4-11(12)10(9)6-8-13;/h2-4H,5-8H2,1H3;1H

InChIKey

JKQKVNMNAIFCFS-UHFFFAOYSA-N

Angaben zum Gen

human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

Anwendung

SKF 86466 was used to study adrenoceptor signaling in rat limbic seizure models.[1][2]

Biochem./physiol. Wirkung

SKF 86466 binds specifically to α2-adrenoceptors at pre- and post-junctional sites but was also reported to antagonize α1-aderenoceptors in humans.[3] The structural similarity of receptors enables SKF 86466 binding to 5-HT1A receptors.[4]

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
100K47141
100K4714

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M S Hedrick et al.
Respiration physiology, 101(2), 129-137 (1995-08-01)
The purpose of this study was to test the hypothesis that respiratory and apneas induced by alpha 2 agonists in anesthetized goats are associated with an increase of upper airway expiratory-related activity, rather than a general depression of breathing. Activities
Ellen W King et al.
Pain, 115(3), 364-373 (2005-05-25)
The alpha2A and alpha2C adrenergic receptor (AR) subtypes mediate antinociception when activated by the endogenous ligand norepinephrine. These receptors also produce antinociceptive synergy when activated concurrently with opioid receptor activation. The involvement of the opioid receptors in the mechanisms governing
He Zhu et al.
Brain research, 964(1), 9-20 (2003-02-08)
Moxonidine is a centrally-active imidazoline compound with preferential affinity for imidazoline receptors (IR) over alpha(2)-adrenoceptors (alpha(2)AR). Clinically, moxonidine has proven advantageous for treating hypertension over pure alpha(2)-adrenergic agonists (i.e., guanabenz) due to its lowered incidence of sedative side effects. The
M A Haxhiu et al.
Advances in experimental medicine and biology, 454, 467-473 (1999-01-16)
In these studies we determined the effects of local hypoxia confined to the superficial structures of the ventral medulla on cholinergic outflow to the airways. Studies were performed in alpha-chloralose anesthetized, paralyzed and mechanically ventilated cats. Topical application or microinjection
Katarzyna Kaczyñska et al.
Experimental physiology, 91(1), 269-275 (2005-11-12)
The respiratory effects of stimulation of alpha2-adrenergic receptors were studied in spontaneously breathing anaesthetized rats that were neurally intact, or bilaterally vagotomized, or subjected to bilateral combined midcervical vagotomy and section of the carotid sinus nerves. An intravenous clonidine bolus
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