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S1195

Sigma-Aldrich

ST638

≥98% (HPLC), solid

Synonym(e):

α-Cyano-(3-ethoxy-4-hydroxy-5-phenylthiomethyl)cinnamide

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About This Item

Empirische Formel (Hill-System):
C19H18N2O3S
CAS-Nummer:
107761-24-0
Molekulargewicht:
354.42
MDL-Nummer:
MFCD00236446
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329824465
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

solid

Farbe

yellow

mp (Schmelzpunkt)

134-135.5 °C

Löslichkeit

DMSO: 19 mg/mL

Lagertemp.

−20°C

SMILES String

CCOc1cc(cc(CSc2ccccc2)c1O)\C=C(/C#N)C(N)=O

InChI

1S/C19H18N2O3S/c1-2-24-17-10-13(8-14(11-20)19(21)23)9-15(18(17)22)12-25-16-6-4-3-5-7-16/h3-10,22H,2,12H2,1H3,(H2,21,23)/b14-8+

InChIKey

YKLMGKWXBLSKPK-RIYZIHGNSA-N

Biochem./physiol. Wirkung

Protein tyrosine kinase inhibitor (IC50 = 370 nM). Also inhibits HGF-induced MAP kinase activation in hepatocytes and inhibits phospholipase D activity in human neutrophils.

Verpackung

Light sensitive and packaged under nitrogen.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

R Nakaike et al.
The American journal of physiology, 271(1 Pt 2), H296-H302 (1996-07-01)
The effects of sodium orthovanadate, an inhibitor of protein tyrosine phosphatases, on the endothelial nitric oxide (NO) pathway were studied in vitro. Vanadate caused endothelium-dependent relaxations in isolated porcine coronary arteries, which were abolished by N omega-nitro-L-arginine methyl ester. The
S V Smirnov et al.
Circulation research, 76(2), 310-316 (1995-02-01)
The whole-cell patch-clamp technique was used to characterize the effects of several tyrosine kinase inhibitors on the voltage-gated K+ current (IK) in rat and rabbit pulmonary artery cells. IK was blocked in a dose-dependent manner by genistein (20 to 100
A Burke-Gaffney et al.
British journal of pharmacology, 119(6), 1149-1158 (1996-11-01)
1. Tumour necrosis factor-alpha (TNF alpha) increases the expression of the adhesion molecule intercellular adhesion molecule-1 (ICAM-1) on cultured endothelial and epithelial cells and modulation of this may be important in controlling inflammation. Activation of tyrosine kinase(s) is known to
T Yamawaki et al.
Journal of the American College of Cardiology, 32(3), 780-786 (1998-09-19)
This study was designed to examine whether or not intramural delivery of ST638 (a specific tyrosine kinase inhibitor) with biodegradable stent can suppress the restenotic changes of the coronary artery in vivo. Clinical and animal studies demonstrated that restenosis after
A Ito et al.
The Journal of clinical investigation, 96(3), 1288-1294 (1995-09-01)
We recently demonstrated that chronic treatment with IL-1 beta induces coronary arteriosclerotic changes and vasospastic responses to autacoids in pigs in vivo and that those responses are importantly mediated by PDGF. The receptors for PDGF and other major growth factors
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