S101

(R)-(+)-SKF-38393 hydrochloride

≥98% (HPLC), solid

• Empirische Formel (Hill-System): C₁₆H₁₇NO₂ · HCl
• CAS-Nummer: 81702-42-3
• Molekulargewicht: 291.77
• NACRES: NA.77
• PubChem Substance ID: 329824192
• UNSPSC Code: 12352200
• MDL number: MFCD00055189
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: desiccated

Eigenschaften

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• optical activity: [α]22/D +16.1°, c = 1.2 in methanol(lit.)
• storage condition: desiccated
• color: off-white to light tan
• solubility: 0.1 M HCl: 1.2 mg/mL, ethanol: 3.4 mg/mL, H₂O: 5 mg/mL, aqueous base: unstable
• SMILES string: Cl.Oc1cc2CCNC[C@H](c3ccccc3)c2cc1O
• InChI: 1S/C16H17NO2.ClH/c18-15-8-12-6-7-17-10-14(13(12)9-16(15)19)11-4-2-1-3-5-11;/h1-5,8-9,14,17-19H,6-7,10H2;1H/t14-;/m1./s1
• InChI key: YEWHJCLOUYPAOH-PFEQFJNWSA-N

Beschreibung

Application

(R)-(+)-SKF-38393 hydrochloride has been used as a D1 dopamine receptor agonist to study its effect on the sleep-wake pattern of macaques rendered parkinsonian with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).[1]

Biochem/physiol Actions

(R)-(+)-SKF-38393 hydrochloride is a D1 dopamine receptor agonist [1] and an active enantiomer of (±)-SKF-38393. It enhances pertussis toxin-insensitive and protein kinase A-mediated glutamate release in the hippocampal neurons.[2] SKF-38393, a benzazepine derivative,[3] exhibits anorectic effects.[4]

Features and Benefits

This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Solutions may be stored for several days at 4 °C.

Disclaimer

Light sensitive

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves