PZ0218

PF-03814735

≥98% (HPLC)

• Synonym(e): N-[2-[(1S,4R)-6-[[4-(Cyclobutylamino)-5-(trifluoromethyl)-2-pyrimidinyl]amino]-1,2,3,4-tetrahydronaphthalen-1,4-imin-9-yl]-2-oxoethyl]-acetamide
• Empirische Formel (Hill-System): C₂₃H₂₅F₃N₆O₂
• CAS-Nummer: 942487-16-3
• Molekulargewicht: 474.48
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 20 mg/mL, clear
• Lagertemp.: −20°C
• SMILES String: FC(F)(F)c1c(nc(nc1)Nc3cc4c(cc3)[C@H]5N([C@@H]4CC5)C(=O)CNC(=O)C)NC2CCC2
• InChI: 1S/C23H25F3N6O2/c1-12(33)27-11-20(34)32-18-7-8-19(32)16-9-14(5-6-15(16)18)30-22-28-10-17(23(24,25)26)21(31-22)29-13-3-2-4-13/h5-6,9-10,13,18-19H,2-4,7-8,11H2,1H3,(H,27,33)(H2,28,29,30,31)/t18-,19+/m0/s1
• InChIKey: RYYNGWLOYLRZLK-RBUKOAKNSA-N

Beschreibung

Biochem./physiol. Wirkung

PF-03814735 is a potent inhibitor of Aurora kinase A and B (IC₅₀ = 5 and 0.8 nM, respectively). PF-03814735 inhibits proliferation of tumor cells in culture and in xenograft tumor models. The compound PF-03814735 blocks phosphorylation of Aurora B and Histone H3, and leads to the formation of polyploid cells in culture (HCT116 and MDA-MB-231).

PF-03814735 is a potent inhibitor of Aurora kinase A and B.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable