P8615

Phosphoinositide 3-kinase p110γ human

≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, buffered aqueous glycerol solution

• Synonym(e): PI3K p110γ human, Phosphatidylinositol 3-kinase p110γ human
• MDL-Nummer: MFCD03457993
• UNSPSC-Code: 12352207
• NACRES: NA.32

Eigenschaften

• Rekombinant: expressed in baculovirus infected insect cells
• Qualitätsniveau: 200
• Assay: ≥95% (SDS-PAGE)
• Form: buffered aqueous glycerol solution
• Spezifische Aktivität: ~4.5 units/mg protein
• UniProt-Hinterlegungsnummer: P48736
• Versandbedingung: dry ice
• Lagertemp.: −70°C
• Angaben zum Gen: human ... PIK3CG(5294)

Beschreibung

Allgemeine Beschreibung

Phosphatidylinositol 3-kinase p110γ /phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit γ (PIK3CG) gene, with 12 exons spanning 43 kb on genomic DNA, is mapped to human chromosome 7q22.3. PIK3CG belongs to the family of genes coding for enzymes that phosphorylate the 3′-hydroxyl of phosphatidylinositol.

Biochem./physiol. Wirkung

PI 3-kinases have been implicated in diverse cellular responses triggered by mammalian cell surface receptors. Inhibits NF-κB, AP-1, and STAT1α mediated gene expression induced by IFN-γ resulting in inhibition of COX-2 and NOS ll (iNOS) expression.

Phosphatidylinositol 3-kinase p110γ is implicated in the development of eosinophilic inflammation. Thus, inhibition of PI3Kγ expression can be considered as a potential therapeutic method for treating eosinophil-related diseases, including asthma. Knockdown of PIK3CG gene inhibits the PI3K-Akt/PKB signaling pathway, which is essential for tumorigenesis and the progression of colorectal cancers. Mutation in the gene is associated with the development of autistic disorder.

PI 3-kinases have been implicated in diverse cellular responses triggered by mammalian cell surface receptors. Inhibits NF-κB, AP-1, and STAT1α mediated gene expression induced by IFN-γ resulting in inhibition of COX-2 and NOS ll (iNOS) expression.

Einheitendefinition

1 unit will transfer 1 nmol of phosphate/min, using phosphatidylinositol as substrate.

Physikalische Form

Solution in 10 mM HEPES, pH 7.5, 100 mM NaCl, 0.5 mM MgCl2, 50% glycerol.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable