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P7778

Sigma-Aldrich

Phospholipase A2 aus Naja mossambica mossambica

lyophilized powder, ~1,500 units/mg protein

Synonym(e):

PLA2

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About This Item

CAS-Nummer:
9001-84-7
EC-Nummer:
3.1.1.4 (BRENDA, IUBMB)
EG-Nummer:
232-637-7
MDL-Nummer:
MFCD00131890
UNSPSC-Code:
12352204

Form

lyophilized powder

Spezifische Aktivität

~1,500 units/mg protein

Zusammensetzung

Protein, ~90%

pI 

8.8 (isoenzyme)

Lagertemp.

−20°C

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Biochem./physiol. Wirkung

Hydrolyzes the β-ester bond of zwitterionic glycerophospholipids. Preferred substrates are phosphatidylcholine, phosphatidylethanolamine, and their plasmalogen analogues. Phosphatidylinositol and phosphatidylserine are also hydrolyzed. Aggressively attacks phospholipids in membranes of intact cells.

Sonstige Hinweise

The toxic phospholipase A2 from Naja mossambica mossambica.

Einheitendefinition

One unit will hydrolyze 1.0 μmole of soybean L-α-phosphatidylcholine to L-α-lysophosphatidylcholine and a fatty acid per min at pH 8.9 at 25 °C.

Hinweis zur Analyse

Protein determined by biuret.

Inhibitor

Produkt-Nr.
Beschreibung
Preisangaben

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Chie Aoki-Utsubo et al.
Bio-protocol, 8(10), e2855-e2855 (2018-05-20)
In a narrow definition, virucidal activity represents the activity by which to interact with and physically disrupt viral particles. In a broad definition, it includes the activity by which to functionally inhibit (neutralize) viral infectivity without apparent morphological alterations of
Florian Bleffert et al.
eLife, 11 (2022-05-11)
Cells steadily adapt their membrane glycerophospholipid (GPL) composition to changing environmental and developmental conditions. While the regulation of membrane homeostasis via GPL synthesis in bacteria has been studied in detail, the mechanisms underlying the controlled degradation of endogenous GPLs remain
Ming Chen et al.
Scientific reports, 7(1), 15931-15931 (2017-11-23)
Hepatitis C virus (HCV), dengue virus (DENV) and Japanese encephalitis virus (JEV) belong to the family Flaviviridae. Their viral particles have the envelope composed of viral proteins and a lipid bilayer acquired from budding through the endoplasmic reticulum (ER). The
Willem van de Veen et al.
The Journal of allergy and clinical immunology, 131(4), 1204-1212 (2013-03-05)
IL-10-producing regulatory B cells suppress immune responses, and lack of these cells leads to exacerbated symptoms in mouse models of chronic inflammation, transplantation, and chronic infection. IgG4 is a blocking antibody isotype with anti-inflammatory potential that is induced in human
R Grataroli et al.
European journal of biochemistry, 122(1), 111-117 (1982-02-01)
Upon tryptic activation of pure human prophospholipase A2, a heptapeptide is released from the N-terminal part of the protein yielding active phospholipase A2 (EC 3.1.1.4). Both the kinetics of the activation process and the amino acid sequence of the activation
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