P4668

Praziquantel

anthelminic, neurogenic

• Synonym(e): 2-(Cyclohexylcarbonyl)-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isochinolin-4-on
• Empirische Formel (Hill-System): C₁₉H₂₄N₂O₂
• CAS-Nummer: 55268-74-1
• Molekulargewicht: 312.41
• Beilstein: 761557
• EG-Nummer: 259-559-6
• MDL-Nummer: MFCD00058531
• UNSPSC-Code: 51452701
• PubChem Substanz-ID: 24278635
• NACRES: NA.85

Eigenschaften

• Form: powder or crystals
• Wirkungsspektrum von Antibiotika: parasites
• Wirkungsweise: cell membrane | interferes
• Lagertemp.: −20°C
• SMILES String: O=C1CN(CC2N1CCc3ccccc23)C(=O)C4CCCCC4
• InChI: 1S/C19H24N2O2/c22-18-13-20(19(23)15-7-2-1-3-8-15)12-17-16-9-5-4-6-14(16)10-11-21(17)18/h4-6,9,15,17H,1-3,7-8,10-13H2
• InChIKey: FSVJFNAIGNNGKK-UHFFFAOYSA-N

Beschreibung

Anwendung

Praziquantel is a potent anthelmintic used against schistosome and many cestode infestations. It is used to study voltage-gated Ca²⁺ channels and is a potential small molecule neurogenic.

Biochem./physiol. Wirkung

Praziquantel increases the permeability of the tegmentum to Ca²⁺ which results in the contraction of schistosomes and death. Praziquantel causes vacuolization and disintegration of the schistosome tegument. It is more effective on adult worms than young worms. It inhibits glucose uptake, which lowers glycogen levels and stimulates lactate release. Praziquantel is a potent anthelmintic against parasitic flatworms (flukes and tapeworms). Recent studies have indicated that praziquantel binds to a varient of the β-subunit of the voltage gated Ca²⁺ channel and to actin, which is a component of some Ca²⁺ channels.

Sonstige Hinweise

1g,5g,25g

Keep container tightly closed in a dry and well-ventilated place.

Sicherheitshinweise

• H-Sätze: H412
• P-Sätze: P273 - P501
• Gefahreneinstufungen: Aquatic Chronic 3
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 1
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)