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P4484

Sigma-Aldrich

Purvalanol A

≥98% (HPLC), powder

Synonym(e):

2-(1R-Isopropyl-2-hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine, NG-60

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About This Item

Empirische Formel (Hill-System):
C19H25ClN6O
CAS-Nummer:
212844-53-6
Molekulargewicht:
388.89
MDL-Nummer:
MFCD02179211
UNSPSC-Code:
12352200
PubChem Substanz-ID:
24898543
NACRES:
NA.77

Assay

≥98% (HPLC)

Form

powder

Löslichkeit

methylene chloride: 50 mg/mL

Versandbedingung

dry ice

Lagertemp.

−20°C

SMILES String

CC(C)[C@H](CO)Nc1nc(Nc2cccc(Cl)c2)c3ncn(C(C)C)c3n1

InChI

1S/C19H25ClN6O/c1-11(2)15(9-27)23-19-24-17(22-14-7-5-6-13(20)8-14)16-18(25-19)26(10-21-16)12(3)4/h5-8,10-12,15,27H,9H2,1-4H3,(H2,22,23,24,25)/t15-/m0/s1

InChIKey

PMXCMJLOPOFPBT-HNNXBMFYSA-N

Biochem./physiol. Wirkung

Purvalanol A is found to inhibit ABCG2 (ATP-binding cassette G2) transporter in vitro. It is also known to attenuate cellular Src kinase action and induce cell cycle arrest at the G2 to M phase transition.
Purvalanol A is a potent, cell-permeable cyclin-dependent protein kinase (cdk) inhibitor.

Leistungsmerkmale und Vorteile

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

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