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Merck

P3043

Sigma-Aldrich

β-Propiolacton

Grade III, 85-90%

Synonym(e):

3-Hydroxypropionsäure-lacton, Hydracrylsäure-β-lacton

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About This Item

Empirische Formel (Hill-System):
C3H4O2
CAS-Nummer:
Molekulargewicht:
72.06
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
12352200

Typ

Grade III

Assay

85-90%

Brechungsindex

n20/D 1.412 (lit.)

bp

162 °C (lit.)

mp (Schmelzpunkt)

−33 °C (lit.)

Dichte

1.146 g/mL at 25 °C (lit.)

Lagertemp.

2-8°C

SMILES String

O=C1CCO1

InChI

1S/C3H4O2/c4-3-1-2-5-3/h1-2H2

InChIKey

VEZXCJBBBCKRPI-UHFFFAOYSA-N

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Vorsicht

Insoluble polymers may form during storage.

Piktogramme

Skull and crossbonesHealth hazard

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 2 Inhalation - Carc. 1B - Eye Irrit. 2 - Skin Irrit. 2

Lagerklassenschlüssel

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flammpunkt (°F)

158.0 °F - closed cup

Flammpunkt (°C)

70 °C - closed cup

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


Analysenzertifikate (COA)

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Joost P Uittenbogaard et al.
The Journal of biological chemistry, 286(42), 36198-36214 (2011-08-27)
β-Propiolactone is often applied for inactivation of viruses and preparation of viral vaccines. However, the exact nature of the reactions of β-propiolactone with viral components is largely unknown. The purpose of the current study was to elucidate the chemical modifications
R Ramya et al.
Vaccine, 27(15), 2138-2143 (2009-04-10)
Rabies is an endemic, fatal zoonotic disease in the developing countries. Oral vaccination strategies are suitable for rabies control in developing countries. Studies were performed to investigate the suitability of poly(lactide-co-glycolide) (PLG) microspheres as an oral delivery system for beta-propiolactone
Ying-Jie Lu et al.
Vaccine, 28(47), 7468-7475 (2010-09-23)
Mucosal immunization with a killed whole-cell pneumococcal vaccine, given with enterotoxin-related adjuvants, has been shown to confer multi-serotype protection against colonization of the nasopharynx and middle ear in mice. However, because novel mucosal immunization strategies may be difficult to implement
E Anderson et al.
Journal of fish diseases, 31(10), 729-745 (2008-08-30)
The inactivation dynamics of infectious haematopoietic necrosis virus (IHNV) by b-propiolactone (BPL), binary ethylenimine (BEI), formaldehyde or heat and the antigenic and immunogenic properties of the inactivated vaccines were evaluated. Chemical treatment of IHNV with 2.7 mm BPL, 1.5 mm
H J M Jagt et al.
Biologicals : journal of the International Association of Biological Standardization, 38(1), 128-134 (2009-09-01)
An in vitro potency test has recently been included in the European Pharmacopoeia (EP) monograph (01/2007:0870) to assess the potency of inactivated Newcastle disease (ND) vaccines. This enzyme linked immunosorbent assay (ELISA) is an attractive alternative for the existing in

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