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O6881

Sigma-Aldrich

Oxypurinol

≥98% (HPLC)

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100 MG
283,00 €
500 MG
784,00 €

283,00 €

Versandbereit am11. April 2025Details

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100 MG
283,00 €
500 MG
784,00 €

About This Item

Empirische Formel (Hill-System):
C5H4N4O2
CAS-Nummer:
2465-59-0
Molekulargewicht:
152.11
EG-Nummer:
219-570-9
MDL-Nummer:
MFCD00056934
UNSPSC-Code:
41106305
PubChem Substanz-ID:
24898041
NACRES:
NA.51

283,00 €

Versandbereit am11. April 2025Details

Bulk-Bestellung anfordern

Qualitätsniveau

200

Assay

≥98% (HPLC)

Form

powder

Löslichkeit

1 M NaOH: 49.00-51.00 mg/mL, clear to slightly hazy, colorless to yellow (heated NaOH)

SMILES String

O=C1NC(=O)c2cn[nH]c2N1

InChI

1S/C5H4N4O2/c10-4-2-1-6-9-3(2)7-5(11)8-4/h1H,(H3,6,7,8,9,10,11)

InChIKey

HXNFUBHNUDHIGC-UHFFFAOYSA-N

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Anwendung

Oxypurinol has been used as a xanthine oxidase inhibitor, to evaluate its effects on hepatocellular carcinoma cell proliferation.[1] It has also been used as a xanthine inhibitor to elucidate its contribution in the induction of hpv16 late gene expression.[2]
Oxypurinol, an allopurinol metabolite, is used as an inhibitor to study the specificity and kinetics of of xanthine oxidase(s). Oxypurinol is also used as an anti-inflammatory agent via inhibition of xanthine oxidase.

Biochem./physiol. Wirkung

An allopurinol metabolite.
Oxypurinol has the ability to stimulate osteoblast differentiation and enhance the formation of bone. It is used to treat gout and hyperuricemia. Oxypurinol is considered as a strong antioxidant. It can prevent the actions of xanthine oxidase (XO) in osteoblasts.[3]

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Zielorgane

Respiratory system

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000380103
0000320100
0000320099
0000309357
0000380103

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Spermidin BioReagent, suitable for cell culture, ≥98%

Sigma-Aldrich

S0266

Spermidin

Ibuprofen ≥98% (GC)

Sigma-Aldrich

I4883

Ibuprofen

Paolo Puddu et al.
Journal of cardiology, 59(3), 235-242 (2012-03-09)
Uric acid is the end product of purine metabolism. Its immediate precursor, xanthine, is converted to uric acid by an enzymatic reaction involving xanthine oxidoreductase. Uric acid has been formerly considered a major antioxidant in human plasma with possible beneficial
Jan B Derks et al.
Pediatric research, 68(5), 374-380 (2010-07-09)
In complicated labor, neonatal outcome may depend not only on the extent of fetal asphyxia and acidosis but also on the effects on the fetal cardiovascular system of reactive oxygen species (ROS) generated during the ischemia-reperfusion (I/R) associated with repeated
L K Stamp et al.
Clinical pharmacology and therapeutics, 90(3), 392-398 (2011-07-29)
The treatment of gout requires a lowering of serum urate (SU) levels, and allopurinol is the drug that is most commonly used for this purpose. The objectives of this study were to define the relationships between allopurinol dose on the
Daniel Y Ng et al.
European journal of clinical pharmacology, 67(7), 709-713 (2010-12-25)
To determine whether low-dose aspirin and hydrochlorothiazide (HCTZ) affect the renal clearance of oxypurinol and/or urate. Healthy volunteers (n = 8) were treated with allopurinol (600 mg, control), and allopurinol (600 mg) co-administered with single doses of aspirin (100 mg) or HCTZ (25 mg) or a
Sophie L Stocker et al.
British journal of clinical pharmacology, 74(3), 477-489 (2012-02-04)
Our aim was to identify and quantify the sources of variability in oxypurinol pharmacokinetics and explore relationships with plasma urate concentrations. Non-linear mixed effects modelling was applied to concentration-time data from 155 gouty patients with demographic, medical history and renal
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