N2001

Neostigminbromid

≥98% (HPLC and titration), powder

• Synonym(e): 3-(N,N-Dimethylcarbamoyloxy)-N,N,N,-trimethylanilinium bromide, Prostigmine
• Empirische Formel (Hill-System): C₁₂H₁₉BrN₂O₂
• CAS-Nummer: 114-80-7
• Molekulargewicht: 303.20
• EG-Nummer: 204-054-8
• MDL-Nummer: MFCD00011795
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24277854
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC and titration)
• Form: powder
• Farbe: white
• mp (Schmelzpunkt): 175-177 °C (lit.)
• Löslichkeit: H₂O: 1 g/mL; ethanol: soluble
• SMILES String: [Br-].CN(C)C(=O)Oc1cccc(c1)[N+](C)(C)C
• InChI: 1S/C12H19N2O2.BrH/c1-13(2)12(15)16-11-8-6-7-10(9-11)14(3,4)5;/h6-9H,1-5H3;1H/q+1;/p-1
• InChIKey: LULNWZDBKTWDGK-UHFFFAOYSA-M
• Angaben zum Gen: human ... ACHE(43)

Beschreibung

Anwendung

Neostigmine bromide has been used as an acetyl cholinesterase (AChE) inhibitor:

• to control reaction specificity of acetylcholinesterase in coronal organ of Botryllus schlosseri.
• to study its effects on abnormal contraction of pyloric circular smooth muscle strips (PCSMS).
• to study its effects on depolarization of bag cell neurons.

Biochem./physiol. Wirkung

Reversibler Inhibitor der Acetylcholinesterase; ähnlich zu Eserin, überquert aber nicht die Blut-Hirn-Schranke.

Neostigmine bromide is a quaternary amine. It is involved in elongating and boosting the muscarinic and nicotinic effects of acetylcholine by inhibiting cholinesterase activity. It is used in anesthesia to reverse the neuromuscular blockade produced by competitive neuromuscular blockers.

Leistungsmerkmale und Vorteile

This compound is featured on the Acetylcholine Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS06,GHS08
• Signalwort: Danger
• H-Sätze: H300 + H310 + H330,H315,H317,H319,H334,H335
• P-Sätze: P260 - P262 - P280 - P302 + P352 + P310 - P304 + P340 + P310 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges