M9066

Microsomes from Liver, Pooled

from rat(Sprague-Dawley), male

• Synonym(e): Liver microsome preparation
• UNSPSC-Code: 12161501
• NACRES: NA.47

Eigenschaften

• Biologische Quelle: rat (Sprague-Dawley)
• Qualitätsniveau: 200
• Form: liquid
• Verpackung: vial of ~10 mg
• Versandbedingung: dry ice
• Lagertemp.: −70°C

Beschreibung

Allgemeine Beschreibung

Microsomes are the fraction of "submicroscopic” particles isolated from homogenates of liver and other tissues. Microsomes are rich in ribonucleic acid (RNA).

Anwendung

Microsomes from Liver, Pooled has been used in following studies:

• inhibition of microsomal lipid peroxidation.
• hydroxylation of isorhynchophylline (ISOR) in rats.

Biochem./physiol. Wirkung

Liver microsomes are subcellular particles derived from the endoplasmic reticulum of hepatic cells. These microsomes are a rich source of drug metabolizing enzymes, including cytochrome P-450. Microsome pools from various sources are useful in the study of xenobiotic metabolism and drug interactions.

Microsomes might act as cell organelles and are actively involved in protein synthesis. Carbon monoxide-binding pigment of microsomes, named P-450, is an integral element of mixed function oxidase systems involved in the oxidative demethylation and hydroxylation of drugs and steroids. Murine liver microsomes plays a crucial role in degradation of small antimicrobial β^2,2-amino acid derivatives.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable