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Wichtige Dokumente
M8523
Anti-β2-Microglobulin antibody produced in rabbit
whole antiserum
Synonym(e):
Anti-B2MG
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About This Item
Biologische Quelle
rabbit
Konjugat
unconjugated
Antikörperform
whole antiserum
Antikörper-Produkttyp
primary antibodies
Klon
polyclonal
Enthält
15 mM sodium azide
Speziesreaktivität
human
Verpackung
antibody small pack of 25 μL
Methode(n)
indirect ELISA: 1:5,000
UniProt-Hinterlegungsnummer
Versandbedingung
dry ice
Lagertemp.
−20°C
Posttranslationale Modifikation Target
unmodified
Angaben zum Gen
human ... B2M(567)
Allgemeine Beschreibung
β-2-microglobulin is part of the human leukocyte antigen, where it represents the light chain. It is expressed on cell membranes and is made up of 99 amino acids. β-2-microglobulin is part of the immunoglobulin superfamily.
β2-microglobulin (B2M) is a non-glycosylated polypeptide. The protein is characterized with a single polypeptide chain, which is linked noncovalently to major histocompatibility complex (MHC) class I cell surface antigen. The gene coding for B2M is mapped to human chromosome 15q.
Immunogen
β2-microglobulin
Anwendung
Anti-β2-Microglobulin antibody produced in rabbit has been used in immunoblotting[1]and immunofluorescence.
Biochem./physiol. Wirkung
β-2-microglobulin acts as a tumor marker and has been shown to be associated with dialysis-related amyloidosis.
β2-microglobulin (B2M) plays a vital role in cell survival, proliferation and metastasis in various types of cancer. Elevated concentration of β-2-microglobulin (B2M) can be considered as a prognostic marker for hemophagocytic lymphohistiocytosis (HLH). Overexpression of serum B2M is observed in hepatitis C virus (HCV) related chronic liver diseases, therefore it might act as a potential marker for the HCV disease progression towards cirrhosis and carcinoma. Missense mutation in the B2M gene results in familial hypercatabolic hypoproteinemia (FHH).
Qualität
The antiserum has been treated to remove lipoprotens.
Haftungsausschluss
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Lagerklassenschlüssel
10 - Combustible liquids
WGK
WGK 3
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Damien G Noone et al.
Kidney international, 90(1), 123-134 (2016-05-30)
Atypical hemolytic uremic syndrome and thrombotic thrombocytopenic purpura have traditionally been considered separate entities. Defects in the regulation of the complement alternative pathway occur in atypical hemolytic uremic syndrome, and defects in the cleavage of von Willebrand factor (VWF)-multimers arise
The prognostic significance of Beta2 microglobulin in patients with hemophagocytic lymphohistiocytosis
Jiang T, et al.
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Expression of the neonatal Fc-receptor in placental-fetal endothelium and in cells of the placental immune system
Kiskova T, et al.
Placenta, 78, 36-43 (2019)
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