M4074

Mometasonfuroat

≥98% (HPLC)

• Synonym(e): (11β,16α)-9,21-Dichlor-17-[(2-furanylcarbonyl)-oxy]-11-hydroxy-16-methylpregna-1,4-dien-3,20-dion
• Empirische Formel (Hill-System): C₂₇H₃₀Cl₂O₆
• CAS-Nummer: 83919-23-7
• Molekulargewicht: 521.43
• MDL-Nummer: MFCD00866003
• UNSPSC-Code: 51111800
• PubChem Substanz-ID: 329817988
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Optische Aktivität: [α]/D +50 to +60°, c = 0.5 in methanol
• Farbe: white to off-white
• Löslichkeit: DMSO: ≥20 mg/mL
• Ersteller: Schering Plough
• Lagertemp.: 2-8°C
• SMILES String: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(Cl)[C@@H](O)C[C@]2(C)[C@@]1(OC(=O)c5ccco5)C(=O)CCl
• InChI: 1S/C27H30Cl2O6/c1-15-11-19-18-7-6-16-12-17(30)8-9-24(16,2)26(18,29)21(31)13-25(19,3)27(15,22(32)14-28)35-23(33)20-5-4-10-34-20/h4-5,8-10,12,15,18-19,21,31H,6-7,11,13-14H2,1-3H3/t15-,18+,19+,21+,24+,25+,26+,27+/m1/s1
• InChIKey: WOFMFGQZHJDGCX-ZULDAHANSA-N
• Angaben zum Gen: human ... NR3C1(2908)

Beschreibung

Anwendung

Mometasone furoate has been used to study its effect on Leishmania major amastigotes.[1]

Biochem./physiol. Wirkung

Mometasonfuroat ist ein entzündungshemmendes Glucocorticoid.

Mometasone furoate is a 17-heterocyclic intranasal corticosteroid. It is effectively used as a first-line daily intranasal therapeutic for allergic rhinitis and nasal polyposis. Mometasone furoate is also used as an adjunct to anti-bacterials for treating acute rhinosinusitis.[2] In addition, it relieves the symptoms of asthma in both adults and adolescents by exhibiting a broad spectrum of anti-inflammatory properties.[3]

Leistungsmerkmale und Vorteile

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Danger
• H-Sätze: H360D
• P-Sätze: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Gefahreneinstufungen: Repr. 1B
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable